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Journal of Neuroscience, Vol 15, 2141-2156, Copyright © 1995 by Society for Neuroscience
Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules
AF Struyk, PD Canoll, MJ Wolfgang, CL Rosen, P D'Eustachio and JL Salzer
Department of Cell Biology, New York University Medical School, New York 10016.
Previous studies in the laboratory indicated that
glycosylphosphatidylinositol (GPI)-anchored proteins may generate diversity
of the cell surface of different neuronal populations (Rosen et al., 1992).
In this study, we have extended these findings and surveyed the expression
of GPI-anchored proteins in the developing rat CNS. In addition to several
well characterized GPI-anchored cell adhesion molecules (CAMs), we detected
an unidentified broad band of 65 kDa that is the earliest and most
abundantly expressed GPI-anchored species in the rat CNS. Purification of
this protein band revealed that it is comprised of several related proteins
that define a novel subfamily of immunoglobulin-like (Ig) CAMs. One of
these proteins is the opiate binding-cell adhesion molecule (OBCAM). We
have isolated a cDNA encoding a second member of this family, that we have
termed neurotrimin, and present evidence for the existence of additional
family members. Like OBCAM, with which it shares extensive sequence
identity, neurotrimin contains three immunoglobulin-like domains. Both
proteins are encoded by distinct genes that may be clustered on the
proximal end of mouse chromosome 9. Characterization of the expression of
neurotrimin and OBCAM in the developing CNS by in situ hybridization
reveals that these proteins are differentially expressed during
development. Neurotrimin is expressed at high levels in several developing
projection systems: in neurons of the thalamus, subplate, and lower
cortical laminae in the forebrain and in the pontine nucleus, cerebellar
granule cells, and Purkinje cells in the hindbrain. Neurotrimin is also
expressed at high levels in the olfactory bulb, neural retina, dorsal root
ganglia, spinal cord, and in a graded distribution in the basal ganglia and
hippocampus. OBCAM has a much more restricted distribution, being expressed
at high levels principally in the cortical plate and hippocampus. These
results suggest that these proteins, together with other members of this
family, provide diversity to the surfaces of different neuronal populations
that could be important in the specification of neuronal connectivity.
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