 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 2985-2994, Copyright © 1995 by Society for Neuroscience
Neuronal regeneration enhances the expression of the immunophilin FKBP- 12
WE Lyons, JP Steiner, SH Snyder and TM Dawson
Division of Toxicological Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland, USA.
Immunophilins are a group of proteins that serve as receptors for the
immunosuppressant drugs cyclosporin A and FK506. The immunophilin
designated FK-506 binding protein-12 (FKBP-12) is concentrated more than 10
times higher in the brain than in immune tissues. The complex of FK506 and
FKBP-12 inhibits the calcium activated phosphatase, calcineurin, increasing
phosphorylated levels of calcineurin substrates with growth associated
protein-43 (GAP-43), being most prominent in the brain. We now demonstrate
an association of FKBP-12 with neuronal regeneration and GAP-43
disposition. Facial nerve crush markedly augments expression of FKBP-12
mRNA in the facial nucleus with a time course paralleling changes in GAP-43
mRNA. Following sciatic nerve lesions, similar increases in FKBP-12 mRNA
occur in lumbar motor neurons and dorsal root ganglia neuronal cells.
Increased FKBP-12 expression appears linked to regeneration rather than
degeneration as facial nerve lesions elicited by ricin injection, which
produce neuronal death without regeneration, fail to augment FKBP-12
expression in the facial nucleus. The time course for accumulation of
FKBP-12 in sciatic nerve segments following nerve crush indicates rapid
axonal transport at a rate similar to GAP-43.
This article has been cited by other articles:
|
|
|
|
 
S. Bollini, J. J. Herbst, G. T. Gaughan, T. A. Verdoorn, J. Ditta, G. M. Dubowchik, and A. Vinitsky
High-Throughput Fluorescence Polarization Method for Identification of FKBP12 Ligands
J Biomol Screen,
December 1, 2002;
7(6):
526 - 530.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Shiraishi, T. Yanagita, H. Kobayashi, Y. Uezono, H. Yokoo, S.-I. Minami, M. Takasaki, and A. Wada
Up-Regulation of Cell Surface Sodium Channels by Cyclosporin A, FK506, and Rapamycin in Adrenal Chromaffin Cells
J. Pharmacol. Exp. Ther.,
April 12, 2001;
297(2):
657 - 665.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
F. Graziani, L. Aldegheri, and G. C. Terstappen
High Throughput Scintillation Proximity Assay for the Identification of FKBP-12 Ligands
J Biomol Screen,
February 1, 1999;
4(1):
3 - 7.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. FANSA, G. KEILHOFF, S. ALTMANN, K. PLOGMEIER, G. WOLF, and W. SCHNEIDER
The Effect of the Immunosuppressant FK 506 on Peripheral Nerve Regeneration Following Nerve Grafting
J Hand Surg Eur Vol.,
February 1, 1999;
24(1):
38 - 42.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. F. Smith, L. Whitesell, and E. Katsanis
Molecular Chaperones: Biology and Prospects for Pharmacological Intervention
Pharmacol. Rev.,
December 1, 1998;
50(4):
493 - 514.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lopez-Ilasaca, C. Schiene, G. Kullertz, T. Tradler, G. Fischer, and R. Wetzker
Effects of FK506-binding Protein 12 and FK506 on Autophosphorylation of Epidermal Growth Factor Receptor
J. Biol. Chem.,
April 17, 1998;
273(16):
9430 - 9434.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Steiner, G. S. Hamilton, D. T. Ross, H. L. Valentine, H. Guo, M. A. Connolly, S. Liang, C. Ramsey, J.-H. J. Li, W. Huang, et al.
Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
PNAS,
March 4, 1997;
94(5):
2019 - 2024.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
.gif?ad=17923&adview=true)
