Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons

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Journal of Neuroscience, Vol 15, 2995-3012, Copyright © 1995 by Society for Neuroscience

ARTICLE

Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons

A Randall and RW Tsien
Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, California 94305, USA.
The diversity of Ca2+ channel types in rat cerebellar granule neurons was investigated with whole-cell recordings (5 mM external Ba2+). Contributions of five different high-voltage-activated Ca2+ channel current components were distinguished pharmacologically. Nimodipine- sensitive L-type current and omega-CTx-GVIA-sensitive N-type current contributed 15 and 20% of the total current, respectively. The bulk of the remaining current (46%) was inhibited by omega-Aga-IVA. The current blocked by this toxin was further subdivided into two components, P- type and Q-type, on the basis of differences in their inactivation kinetics and sensitivity to omega-Aga-IVA. P-Type current was noninactivating during 0.1 sec depolarizations, half-blocked at about 1- 3 nM omega-Aga-IVA, and contributed approximately 11% of the total current; Q-type current was prominently inactivating, half-blocked at approximately 90 nM omega-Aga-IVA, and comprised 35% of the total current. Both P- and Q-type currents were potently inhibited by the Conus magus toxin omega-CTx-MVIIC. A current component resistant to all of the aforementioned blockers (R-type) displayed more rapid inactivation than the other components and constituted 19% of the total current. The Q-type current, the largest of the current components in the granule neurons, resembles currents that can be generated in Xenopus oocytes by expression of cloned alpha 1A subunits.

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Unique Properties of R-Type Calcium Currents in Neocortical and Neostriatal Neurons
J Neurophysiol, November 1, 2000; 84(5): 2225 - 2236.
[Abstract] [Full Text] [PDF]

W.-J. Song, Y. Baba, T. Otsuka, and F. Murakami
Characterization of Ca2+ Channels in Rat Subthalamic Nucleus Neurons
J Neurophysiol, November 1, 2000; 84(5): 2630 - 2637.
[Abstract] [Full Text] [PDF]

K. Melliti, U. Meza, and B. Adams
Muscarinic Stimulation of alpha 1E Ca Channels Is Selectively Blocked by the Effector Antagonist Function of RGS2 and Phospholipase C-beta 1
J. Neurosci., October 1, 2000; 20(19): 7167 - 7173.
[Abstract] [Full Text] [PDF]

S. S. Sidach and I. M. Mintz
Low-Affinity Blockade of Neuronal N-Type Ca Channels by the Spider Toxin omega -Agatoxin-IVA
J. Neurosci., October 1, 2000; 20(19): 7174 - 7182.
[Abstract] [Full Text] [PDF]

J. Martinez-Pinna, E. M McLachlan, and R. Gallego
Distinct mechanisms for activation of Cl- and K+ currents by Ca2+ from different sources in mouse sympathetic neurones
J. Physiol., September 1, 2000; 527(2): 249 - 264.
[Abstract] [Full Text] [PDF]

L. Forti, C. Pouzat, and I. Llano
Action potential-evoked Ca2+ signals and calcium channels in axons of developing rat cerebellar interneurones
J. Physiol., August 15, 2000; 527(1): 33 - 48.
[Abstract] [Full Text] [PDF]

J. B. Bergsman and R. W. Tsien
Syntaxin Modulation of Calcium Channels in Cortical Synaptosomes As Revealed by Botulinum Toxin C1
J. Neurosci., June 15, 2000; 20(12): 4368 - 4378.
[Abstract] [Full Text] [PDF]

A. Stewart and R. C. Foehring
Calcium Currents in Retrogradely Labeled Pyramidal Cells From Rat Sensorimotor Cortex
J Neurophysiol, April 1, 2000; 83(4): 2349 - 2354.
[Abstract] [Full Text] [PDF]

J. J. Plomp, M. N. Vergouwe, A. M. Van den Maagdenberg, M. D. Ferrari, R. R. Frants, and P. C. Molenaar
Abnormal transmitter release at neuromuscular junctions of mice carrying the tottering {alpha}1A Ca2+ channel mutation
Brain, March 1, 2000; 123(3): 463 - 471.
[Abstract] [Full Text] [PDF]

A. Tottene, S. Volsen, and D. Pietrobon
alpha 1E Subunits Form the Pore of Three Cerebellar R-Type Calcium Channels with Different Pharmacological and Permeation Properties
J. Neurosci., January 1, 2000; 20(1): 171 - 178.
[Abstract] [Full Text] [PDF]

P. G. Mermelstein, H. Bito, K. Deisseroth, and R. W. Tsien
Critical Dependence of cAMP Response Element-Binding Protein Phosphorylation on L-Type Calcium Channels Supports a Selective Response to EPSPs in Preference to Action Potentials
J. Neurosci., January 1, 2000; 20(1): 266 - 273.
[Abstract] [Full Text] [PDF]

K. Jun, E. S. Piedras-Renteria, S. M. Smith, D. B. Wheeler, S. B. Lee, T. G. Lee, H. Chin, M. E. Adams, R. H. Scheller, R. W. Tsien, et al.
Ablation of P/Q-type Ca2+ channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha 1A-subunit
PNAS, December 21, 1999; 96(26): 15245 - 15250.
[Abstract] [Full Text] [PDF]

G. Wang, G. Dayanithi, R. Newcomb, and J. R. Lemos
An R-Type Ca2+ Current in Neurohypophysial Terminals Preferentially Regulates Oxytocin Secretion
J. Neurosci., November 1, 1999; 19(21): 9235 - 9241.
[Abstract] [Full Text] [PDF]

D. R Ireland
Preferential formation of strong synapses during re-innervation of guinea-pig sympathetic ganglia
J. Physiol., November 1, 1999; 520(3): 827 - 837.
[Abstract] [Full Text] [PDF]

C. G. Acosta and H. S. Lopez
delta Opioid Receptor Modulation of Several Voltage-Dependent Ca2+ Currents in Rat Sensory Neurons
J. Neurosci., October 1, 1999; 19(19): 8337 - 8348.
[Abstract] [Full Text] [PDF]

E. M. Blalock, N. M. Porter, and P. W. Landfield
Decreased G-Protein-Mediated Regulation and Shift in Calcium Channel Types with Age in Hippocampal Cultures
J. Neurosci., October 1, 1999; 19(19): 8674 - 8684.
[Abstract] [Full Text] [PDF]

F. Lehmann-Horn and K. Jurkat-Rott
Voltage-Gated Ion Channels and Hereditary Disease
Physiol Rev, October 1, 1999; 79(4): 1317 - 1372.
[Abstract] [Full Text] [PDF]

J. M. Sullivan
Mechanisms of Cannabinoid-Receptor-Mediated Inhibition of Synaptic Transmission in Cultured Hippocampal Pyramidal Neurons
J Neurophysiol, September 1, 1999; 82(3): 1286 - 1294.
[Abstract] [Full Text] [PDF]