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Journal of Neuroscience, Vol 15, 3075-3083, Copyright © 1995 by Society for Neuroscience
A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb
RM Duvoisin, C Zhang and K Ramonell
Margaret M. Dyson Vision Research Institute, Department of Ophthalmology, Cornell University Medical College, New York, New York 10021, USA.
A novel metabotropic glutamate receptor, mGluR8, was identified by
screening a mouse retina cDNA library. This receptor is most related to
mGluR4, mGluR7, and mGluR6 (74%, 74%, and 70% identical amino acid
residues, respectively). Similar to these receptors, stimulation by L-
glutamate or L-2-amino-4-phosphonobutyrate (L-APB) of Chinese hamster ovary
(CHO) cells stably transfected with mGluR8 result in the inhibition of
forskolin-stimulated adenylyl cyclase. In situ hybridization studies
revealed a strong expression of the mGluR8 gene in the olfactory bulb,
accessory olfactory bulb, and mammillary body. A weaker expression was
found in the retina, and in scattered cells in the cortex and hindbrain.
During development, the distribution of mGluR8 expression was more
widespread. These results extend the diversity of metabotropic glutamate
receptors in the CNS. Because at least two APB receptors are expressed in
the retina, the use of this drug to block selectively the ON pathway needs
to be reconsidered. The pharmacology and expression of mGluR8 in
mitral/tufted cells suggest it could be a presynaptic receptor modulating
glutamate release by these cells at their axon terminals in the entorhinal
cortex.
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