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Journal of Neuroscience, Vol 15, 3490-3499, Copyright © 1995 by Society for Neuroscience
Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes
B Dauwalder and RL Davis
Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030, USA.
Mutations in the Drosophila dunce gene, the structural gene for a cAMP-
specific phosphodiesterase (PDE), disrupt normal learning and memory and
lead to female sterility. Our experiments address a long-standing question
in the genetic dissection of learning and memory of whether dnc is involved
in physiological processes underlying learning. Conditional expression of
dunce transgenes in dnc adults shortly before training significantly
improves learning over nontransgenic controls. Remarkably, behavioral
rescue was also observed after induction of a transgene carrying a rat
counterpart of dunce. Induction of the transgenes in adult dnc females
confers partial rescue of the female sterility phenotype. These data are
consistent with a major physiological requirement for the gene's activity
in the learning process and show that a rat counterpart can substitute
functionally for the Drosophila gene.
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