 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 3490-3499, Copyright © 1995 by Society for Neuroscience
Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes
B Dauwalder and RL Davis
Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030, USA.
Mutations in the Drosophila dunce gene, the structural gene for a cAMP-
specific phosphodiesterase (PDE), disrupt normal learning and memory and
lead to female sterility. Our experiments address a long-standing question
in the genetic dissection of learning and memory of whether dnc is involved
in physiological processes underlying learning. Conditional expression of
dunce transgenes in dnc adults shortly before training significantly
improves learning over nontransgenic controls. Remarkably, behavioral
rescue was also observed after induction of a transgene carrying a rat
counterpart of dunce. Induction of the transgenes in adult dnc females
confers partial rescue of the female sterility phenotype. These data are
consistent with a major physiological requirement for the gene's activity
in the learning process and show that a rat counterpart can substitute
functionally for the Drosophila gene.
This article has been cited by other articles:
|
|
|
|
 
B. van Swinderen
Attention-Like Processes in Drosophila Require Short-Term Memory Genes
Science,
March 16, 2007;
315(5818):
1590 - 1593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Ganguly-Fitzgerald, J. Donlea, and P. J. Shaw
Waking experience affects sleep need in Drosophila.
Science,
September 22, 2006;
313(5794):
1775 - 1781.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Wang and Y. Zhong
TARGETing "When" and "Where"
Sci. Signal.,
February 17, 2004;
2004(220):
pe5 - pe5.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Mao, G. Roman, L. Zong, and R. L. Davis
Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch
PNAS,
January 6, 2004;
101(1):
198 - 203.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Roman, K. Endo, L. Zong, and R. L. Davis
P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster
PNAS,
October 23, 2001;
98(22):
12602 - 12607.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. DeZazzo, S. Xia, J. Christensen, K. Velinzon, and T. Tully
Developmental Expression of an amn+ Transgene Rescues the Mutant Memory Defect of amnesiac Adults
J. Neurosci.,
October 15, 1999;
19(20):
8740 - 8746.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Preat
Decreased Odor Avoidance after Electric Shock in Drosophila Mutants Biases Learning and Memory Tests
J. Neurosci.,
October 15, 1998;
18(20):
8534 - 8538.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hanks, C. Loomis, E Harris, C. Tong, L Anson-Cartwright, A Auerbach, and A Joyner
Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development
Development,
January 11, 1998;
125(22):
4521 - 4530.
[Abstract]
[PDF]
|
|
|
|
|
|
|
W Li, T Tully, and D Kalderon
Effects of a conditional Drosophila PKA mutant on olfactory learning and memory.
Learn. Mem.,
January 1, 1996;
2(6):
320 - 333.
[Abstract]
[PDF]
|
|
|
|
