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Journal of Neuroscience, Vol 15, 3539-3547, Copyright © 1995 by Society for Neuroscience
Activity-dependent reduction in voltage-dependent calcium current in a crayfish motoneuron
SJ Hong and GA Lnenicka
Department of Biological Sciences, University at Albany, SUNY 12222, USA.
The effect of increased impulse activity upon voltage-dependent Ca2+
currents was studied in the cell body of a crayfish phasic motoneuron using
two-electrode voltage-clamp technique. Increased electrical activity in
this relatively inactive motoneuron produces a short-term and long-term
reduction in the voltage-dependent Ca2+ current. Both forms of
activity-dependent reduction in Ca2+ current are Ca2+ dependent. The
short-term reduction in Ca2+ current appears to involve the
Ca(2+)-dependent inactivation of Ca2+ channels, previously described in a
variety of neurons. The long-term reduction in Ca2+ current is produced by
prolonged Ca2+ influx and persists for days: in vivo stimulation of the
phasic motor axon at 5 Hz for 1 hr results in a 30% reduction in Ca2+
current density, which persists for at least 3 d. Both the short-term and
long-term reductions in Ca2+ current appear to result from changes in a
single type of high-voltage-activated (HVA) Ca2+ channel. Inhibition of
protein synthesis attenuates the long-term reduction in Ca2+ current and
has no effect upon the short-term Ca2+ current reduction. During the
long-term reduction in Ca2+ current, it appears that Ca2+ channels located
distant to the site of Ca2+ influx are affected. The relationship of these
results to a previously described Ca(2+)-dependent reduction in transmitter
release is discussed.
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