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Journal of Neuroscience, Vol 15, 3653-3661, Copyright © 1995 by Society for Neuroscience
Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF
TJ Kilpatrick and PF Bartlett
Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Australia.
Fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF) have
both been reported to stimulate precursors in the developing CNS. To
clarify these effects, we used clonal analysis to determine the lineage
potential of precursors stimulated with each factor, at two stages of
development. It was found that in cells isolated from the cerebrum of
embryonic day 17 (E17) mice, FGF-2 stimulated both a multipotential
precursor, which gave rise to neurons and astrocytes, and a committed glial
precursor. In contrast, EGF only stimulated the glial restricted precursor.
Thus, it appears that the multipotential cell, previously identified to be
present at E10, remains selectively responsive to FGF-2, and that the EGF
responsiveness observed at E17 reflects the presence of a new restricted
class of precursors, rather than a switch in factor specificity of the
multipotential cell.
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