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Journal of Neuroscience, Vol 15, 4298-4314, Copyright © 1995 by Society for Neuroscience
The potassium channel subunit KV3.1b is localized to somatic and axonal membranes of specific populations of CNS neurons
M Weiser, E Bueno, C Sekirnjak, ME Martone, H Baker, D Hillman, S Chen, W Thornhill, M Ellisman and B Rudy
Department of Physiology and Neuroscience, New York University Medical Center, New York 10016, USA.
Potassium channels play major roles in the regulation of many aspects of
neuronal excitability. These channels are particularly well suited for such
multiplicity of roles since there is a large diversity of channel types.
This diversity contributes to the ability of specific neurons (and possibly
different regions of the same neuron) to respond uniquely to a given input.
Neuronal integration depends on the local response of spatially segregated
inputs to the cell and the communication of these integration centers with
the axon. Therefore, the functional implications of a given set of K+
channels varies depending on their precise location on the neuronal
surface. Site- specific antibodies were utilized to characterize the
distribution of KV3.1b, a subunit of voltage-gated K+ channels in CNS
neurons. KV3.1b subunits are expressed in specific neuronal populations of
the rat brain, such as cerebellar granule cells, projecting neurons of deep
cerebellar nuclei, the substantia nigra pars-reticulata, the globus
pallidus, and the ventral thalamus (reticular thalamic nucleus, ventral
lateral geniculate and zona incerta). The KV3.1b protein is also present in
various neuronal populations involved in the processing of auditory
signals, including the inferior colliculus, the nuclei of the lateral
lemniscus, the superior olive, and some parts of the cochlear nuclei; as
well as in several other neuronal groups in the brainstem (e.g., in the
oculomotor nucleus, the pontine nuclei, the reticulotegmental nucleus of
the pons, trigeminal and vestibular nuclei, and the reticular formation)
and subsets of neurons in the neocortex, the hippocampus and the
caudate-putamen shown by double staining to correspond to neurons
containing parvalbumin. KV3.1b subunits are localized predominantly in
somatic and axonal membranes (particularly in axonal terminal fields) but
are much less prominent in dendritic arborizations. This distribution is
different than that of other subunits of voltage gated K+ channels and is
consistent with a role in the modulation of action potentials. KV3.1b
proteins have a cellular and subcellular distribution different than the
related KV3.2 subunits which express in Xenopus oocytes currents similar to
those expressed by KV3.1b.
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