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Journal of Neuroscience, Vol 15, 4488-4495, Copyright © 1995 by Society for Neuroscience
Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin
R Martini, MH Mohajeri, S Kasper, KP Giese and M Schachner
Department of Neurobiology, Swiss Federal Institute of Technology, Zurich.
In search for the molecular mechanisms underlying the formation of the
major dense line in peripheral nerve myelin we investigated mice deficient
in the myelin proteins P0 and MBP. In mice lacking both molecules axons
were enwrapped by myelin-like processes devoid of the major dense line,
while mice deficient in either protein showed, respectively, partial and
normal compaction. Mice heterozygous for P0 but devoid of MBP showed myelin
of reduced thickness around axons of normal caliber. Both molecules thus
contribute to the formation of the major dense line and to the
determination of myelin thickness. Furthermore, our observations modify the
view that axon caliber is dependent on normal myelin.
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