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Journal of Neuroscience, Vol 15, 4658-4677, Copyright © 1995 by Society for Neuroscience
Disconnection of intracortical synaptic linkages disrupts synchronization of a slow oscillation
F Amzica and M Steriade
Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada.
The intracortical synaptic linkages underlying the synchronization of a
recently described slow (< 1 Hz) oscillation (Steriade et al., 1993b,c)
were investigated in anesthetized cats by means of multisite extra- and
intracellular recordings, including dual impalements, from rostral and
caudal sites in the association cortical suprasylvian and marginal gyri,
before and after reversible lidocaine inactivation or transections in the
middle suprasylvian gyrus. Stimulus-evoked responses revealed that the
rostral and caudal suprasylvian foci are reciprocally connected, with a
preference for posterior-to-anterior responses. Lidocaine infusion between
the stimulating and recording sites disrupted the intracortical synaptic
linkage, while leaving unaffected the responses at the sites close to the
stimulating electrodes. The high coherence between slowly oscillating field
potentials and intracellular activities recorded from anterior and
posterior suprasylvian foci was lost after reversible inactivation or
transections in the middle suprasylvian gyrus, whereas the synchrony
between adjacent foci within the anterior or posterior areas was preserved.
Two to four hours after inactivation or transection the synchrony between
all channels was totally or partially recovered. We introduced the
synchrony coefficient (SyCo) and calculated the SyCo for closely located
and distant sites. Lidocaine infusion or transection did not affect the
SyCo between leads placed on the same site, but significantly (60%)
decreased the SyCo between channels separated by the functionally
inactivated or transected sector. Our results demonstrate that pathways
within or beneath the suprasylvian gyrus sustain the synchronization of the
slow oscillation between cortical sites. As the loss of long-range
coherence was not permanent, intergyral paths and/or corticothalamocortical
loops may exert compensatory functions after the disconnection of
intrasuprasylvian synaptic linkages.
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