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Journal of Neuroscience, Vol 15, 4838-4850, Copyright © 1995 by Society for Neuroscience
The mouse mutation reeler causes increased adhesion within a subpopulation of early postmitotic cortical neurons
RM Hoffarth, JG Johnston, LA Krushel and D van der Kooy
Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada.
Early postmitotic cortical neurons are mostly corticofugal projection
neurons that take up positions in deep cortical laminae. Later postmitotic
neurons are preferentially localized to superficial cortical laminae. In
reeler mutant mice it appears that cortical laminar positions with respect
to birthdate are reversed (Caviness, 1982). In a reanalysis of reeler
lamination we found that early postmitotic cortical neurons labeled by
embryonic day (E) 11-13 injections of a birthdate marker, or by early
postnatal day (PND) 2 retrograde labeling through their output projections,
appear to take up positions both in the superficial and deep cortex.
Neurons born on E11 and E12 are more likely to be situated superficially in
the reeler cortex and neurons born on E13 are more likely to be situated in
the deep reeler cortex. Many corticofugal projection neurons in the deep
(but not superficial) reeler cortex either die or retract their axons
before PND 21. We hypothesize that the earliest postmitotic (E11-E12) of
the early postmitotic reeler cortical neurons are overly adhesive and act
as a barrier to later postmitotic migrating neurons. In vitro cortical
aggregation cultures confirmed that early postmitotic (E12) reeler neurons
are more adhesive than early postmitotic (E12) wild-type neurons or late
postmitotic (E16) reeler or wild-type cortical neurons. We suggest that the
moderate wild-type preferential adhesion of early postmitotic cortical
neurons to each other helps deep and superficially fated lineages to form
cortical laminae.
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