 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 4851-4867, Copyright © 1995 by Society for Neuroscience
The orbital and medial prefrontal circuit through the primate basal ganglia
SN Haber, K Kunishio, M Mizobuchi and E Lynd-Balta
Department of Neurobiology and Anatomy, University of Rochester School of Medicine, New York 14642, USA.
The ventral striatum is considered an interface between limbic and motor
systems. We followed the orbital and medial prefrontal circuit through the
monkey basal ganglia by analyzing the projection from this cortical area to
the ventral striatum and the representation of orbitofrontal cortex via the
striatum, in the globus pallidus and substantia nigra. Following injections
of Lucifer yellow and horse radish peroxidase into the medial ventral
striatum, there is a very densely labeled distribution of cells in areas
13a and 13b, primarily in layers V and VI, and in medial prefrontal areas
32 and 25. Injections into the shell of the nucleus accumbens labeled
primarily areas 25 and 32. The reaction product in the globus pallidus and
the substantia nigra supports previous studies demonstrating that efferent
projections from the ventral striatum are represented topographically in
the ventral pallidum and nontopographically in the substantia nigra, pars
compacta. Tritiated amino acid or PHA-L tracer injections into
orbitofrontal cortex produce dense patches of terminal labeling along the
medial edge of the caudate nucleus and the dorsal part of the nucleus
accumbens. These results demonstrate that the orbital prefrontal cortex
projects primarily to the medial edge of the ventral striatum and to the
core of the nucleus accumbens. The arrangement of terminals in the globus
pallidus and substantia nigra show two different patterns. Thus, the
orbital and medial prefrontal cortex is represented in a confined region of
the globus pallidus but throughout an extensive area of the dorsal
substantia nigra. Terminals are extensive throughout the region of the
dopaminergic neurons, suggesting that this input may influence a wide area
of both the striatum and frontal cortex.
This article has been cited by other articles:
|
|
|
|
 
Y. Worbe, N. Baup, D. Grabli, M. Chaigneau, S. Mounayar, K. McCairn, J. Feger, and L. Tremblay
Behavioral and Movement Disorders Induced by Local Inhibitory Dysfunction in Primate Striatum
Cereb Cortex,
December 9, 2008;
(2008)
bhn214v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Di Martino, A. Scheres, D.S. Margulies, A.M.C. Kelly, L.Q. Uddin, Z. Shehzad, B. Biswal, J.R. Walters, F.X. Castellanos, and M.P. Milham
Functional Connectivity of Human Striatum: A Resting State fMRI Study
Cereb Cortex,
December 1, 2008;
18(12):
2735 - 2747.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Simmons, Z. S. Saad, M. J. Lizak, M. Ortiz, A. P. Koretsky, and B. J. Richmond
Mapping Prefrontal Circuits In Vivo with Manganese-Enhanced Magnetic Resonance Imaging in Monkeys
J. Neurosci.,
July 23, 2008;
28(30):
7637 - 7647.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Johansen-Berg, D. A. Gutman, T. E. J. Behrens, P. M. Matthews, M. F. S. Rushworth, E. Katz, A. M. Lozano, and H. S. Mayberg
Anatomical Connectivity of the Subgenual Cingulate Region Targeted with Deep Brain Stimulation for Treatment-Resistant Depression
Cereb Cortex,
June 1, 2008;
18(6):
1374 - 1383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Simmons and B. J. Richmond
Dynamic Changes in Representations of Preceding and Upcoming Reward in Monkey Orbitofrontal Cortex
Cereb Cortex,
January 1, 2008;
18(1):
93 - 103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. B. Kim, N. Huh, H. Lee, E. H. Baeg, D. Lee, and M. W. Jung
Encoding of Action History in the Rat Ventral Striatum
J Neurophysiol,
December 1, 2007;
98(6):
3548 - 3556.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Yacubian, J. Glascher, K. Schroeder, T. Sommer, D. F. Braus, and C. Buchel
Dissociable systems for gain- and loss-related value predictions and errors of prediction in the human brain.
J. Neurosci.,
September 13, 2006;
26(37):
9530 - 9537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. N. Haber, K.-S. Kim, P. Mailly, and R. Calzavara
Reward-Related Cortical Inputs Define a Large Striatal Region in Primates That Interface with Associative Cortical Connections, Providing a Substrate for Incentive-Based Learning.
J. Neurosci.,
August 9, 2006;
26(32):
8368 - 8376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Feekes and M. D. Cassell
The vascular supply of the functional compartments of the human striatum
Brain,
August 1, 2006;
129(8):
2189 - 2201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Levy and B. Dubois
Apathy and the Functional Anatomy of the Prefrontal Cortex-Basal Ganglia Circuits
Cereb Cortex,
July 1, 2006;
16(7):
916 - 928.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Crespo, K. Sturm, A. Saria, and G. Zernig
Activation of muscarinic and nicotinic acetylcholine receptors in the nucleus accumbens core is necessary for the acquisition of drug reinforcement.
J. Neurosci.,
May 31, 2006;
26(22):
6004 - 6010.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N A Shapira, M S Okun, D Wint, K D Foote, J A Byars, D Bowers, U S Springer, P J Lang, B D Greenberg, S N Haber, et al.
Panic and fear induced by deep brain stimulation.
J. Neurol. Neurosurg. Psychiatry,
March 1, 2006;
77(3):
410 - 412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Hikosaka, K. Nakamura, and H. Nakahara
Basal Ganglia Orient Eyes to Reward
J Neurophysiol,
February 1, 2006;
95(2):
567 - 584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. Croxson, H. Johansen-Berg, T. E. J. Behrens, M. D. Robson, M. A. Pinsk, C. G. Gross, W. Richter, M. C. Richter, S. Kastner, and M. F. S. Rushworth
Quantitative Investigation of Connections of the Prefrontal Cortex in the Human and Macaque using Probabilistic Diffusion Tractography
J. Neurosci.,
September 28, 2005;
25(39):
8854 - 8866.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-K. Zubieta, J. A. Bueller, L. R. Jackson, D. J. Scott, Y. Xu, R. A. Koeppe, T. E. Nichols, and C. S. Stohler
Placebo Effects Mediated by Endogenous Opioid Activity on {micro}-Opioid Receptors
J. Neurosci.,
August 24, 2005;
25(34):
7754 - 7762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Mendez, R. Sanchez-Pernaute, O. Cooper, A. Vinuela, D. Ferrari, L. Bjorklund, A. Dagher, and O. Isacson
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease
Brain,
July 1, 2005;
128(7):
1498 - 1510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Francois, D. Grabli, K. McCairn, C. Jan, C. Karachi, E.-C. Hirsch, J. Feger, and L. Tremblay
Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
Brain,
September 1, 2004;
127(9):
2055 - 2070.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Fuchs, K. A. Evans, M. P. Parker, and R. E. See
Differential Involvement of Orbitofrontal Cortex Subregions in Conditioned Cue-Induced and Cocaine-Primed Reinstatement of Cocaine Seeking in Rats
J. Neurosci.,
July 21, 2004;
24(29):
6600 - 6610.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Wichmann and M. A. Kliem
Neuronal Activity in the Primate Substantia Nigra Pars Reticulata During the Performance of Simple and Memory-Guided Elbow Movements
J Neurophysiol,
February 1, 2004;
91(2):
815 - 827.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Schoenbaum and B. Setlow
Lesions of Nucleus Accumbens Disrupt Learning about Aversive Outcomes
J. Neurosci.,
October 29, 2003;
23(30):
9833 - 9841.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Heimer
A New Anatomical Framework for Neuropsychiatric Disorders and Drug Abuse
Am J Psychiatry,
October 1, 2003;
160(10):
1726 - 1739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ravel, E. Legallet, and P. Apicella
Responses of Tonically Active Neurons in the Monkey Striatum Discriminate between Motivationally Opposing Stimuli
J. Neurosci.,
September 17, 2003;
23(24):
8489 - 8497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Shumake and F. Gonzalez-Lima
Brain Systems Underlying Susceptibility to Helplessness and Depression
Behav Cogn Neurosci Rev,
September 1, 2003;
2(3):
198 - 221.
[Abstract]
[PDF]
|
|
|
|
|
|
|
U. E. Ghitza, A. T. Fabbricatore, V. Prokopenko, A. P. Pawlak, and M. O. West
Persistent Cue-Evoked Activity of Accumbens Neurons after Prolonged Abstinence from Self-Administered Cocaine
J. Neurosci.,
August 13, 2003;
23(19):
7239 - 7245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. C. Cromwell and W. Schultz
Effects of Expectations for Different Reward Magnitudes on Neuronal Activity in Primate Striatum
J Neurophysiol,
May 1, 2003;
89(5):
2823 - 2838.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. D. Volkow, L. Chang, G.-J. Wang, J. S. Fowler, Y.-S. Ding, M. Sedler, J. Logan, D. Franceschi, J. Gatley, R. Hitzemann, et al.
Low Level of Brain Dopamine D2 Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex
Focus,
April 1, 2003;
1(2):
150 - 157.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Gusnard, J. M. Ollinger, G. L. Shulman, C. R. Cloninger, J. L. Price, D. C. Van Essen, and M. E. Raichle
Persistence and brain circuitry
PNAS,
March 18, 2003;
100(6):
3479 - 3484.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Black, T. Hershey, J. M. Koller, T. O. Videen, M. A. Mintun, J. L. Price, and J. S. Perlmutter
A possible substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring dopamine agonist
PNAS,
December 24, 2002;
99(26):
17113 - 17118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Walton, D. M. Bannerman, and M. F. S. Rushworth
The Role of Rat Medial Frontal Cortex in Effort-Based Decision Making
J. Neurosci.,
December 15, 2002;
22(24):
10996 - 11003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. R. McFarland and S. N. Haber
Thalamic Relay Nuclei of the Basal Ganglia Form Both Reciprocal and Nonreciprocal Cortical Connections, Linking Multiple Frontal Cortical Areas
J. Neurosci.,
September 15, 2002;
22(18):
8117 - 8132.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Porrino, D. Lyons, M. D. Miller, H. R. Smith, D. P. Friedman, J. B. Daunais, and M. A. Nader
Metabolic Mapping of the Effects of Cocaine during the Initial Phases of Self-Administration in the Nonhuman Primate
J. Neurosci.,
September 1, 2002;
22(17):
7687 - 7694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. McAlonan, E. Daly, V. Kumari, H. D. Critchley, T. v. Amelsvoort, J. Suckling, A. Simmons, T. Sigmundsson, K. Greenwood, A. Russell, et al.
Brain anatomy and sensorimotor gating in Asperger's syndrome
Brain,
July 1, 2002;
125(7):
1594 - 1606.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Schnider, N. Valenza, S. Morand, and C. M. Michel
Early Cortical Distinction between Memories that Pertain to Ongoing Reality and Memories that Don't
Cereb Cortex,
January 1, 2002;
12(1):
54 - 61.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. D. Volkow, L. Chang, G.-J. Wang, J. S. Fowler, Y.-S. Ding, M. Sedler, J. Logan, D. Franceschi, J. Gatley, R. Hitzemann, et al.
Low Level of Brain Dopamine D2 Receptors in Methamphetamine Abusers: Association With Metabolism in the Orbitofrontal Cortex
Am J Psychiatry,
December 1, 2001;
158(12):
2015 - 2021.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. McFarland and P. W. Kalivas
The Circuitry Mediating Cocaine-Induced Reinstatement of Drug-Seeking Behavior
J. Neurosci.,
November 1, 2001;
21(21):
8655 - 8663.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Small, R. J. Zatorre, A. Dagher, A. C. Evans, and M. Jones-Gotman
Changes in brain activity related to eating chocolate: From pleasure to aversion
Brain,
September 1, 2001;
124(9):
1720 - 1733.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Gusnard, E. Akbudak, G. L. Shulman, and M. E. Raichle
Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function
PNAS,
March 16, 2001;
(2001)
71043098.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Bechara, D. Tranel, and H. Damasio
Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions
Brain,
November 1, 2000;
123(11):
2189 - 2202.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Bradberry, R. L. Barrett-Larimore, P. Jatlow, and S. R. Rubino
Impact of Self-Administered Cocaine and Cocaine Cues on Extracellular Dopamine in Mesolimbic and Sensorimotor Striatum in Rhesus Monkeys
J. Neurosci.,
May 15, 2000;
20(10):
3874 - 3883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Tremblay and W. Schultz
Reward-Related Neuronal Activity During Go-Nogo Task Performance in Primate Orbitofrontal Cortex
J Neurophysiol,
April 1, 2000;
83(4):
1864 - 1876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Tremblay and W. Schultz
Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Orbitofrontal Cortex
J Neurophysiol,
April 1, 2000;
83(4):
1877 - 1885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. FISHBEIN
Neuropsychological Function, Drug Abuse, and Violence: A Conceptual Framework
Criminal Justice and Behavior,
April 1, 2000;
27(2):
139 - 159.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. N. Haber, J. L. Fudge, and N. R. McFarland
Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum
J. Neurosci.,
March 15, 2000;
20(6):
2369 - 2382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. W. Van Hoesen, J. Parvizi, and C.-C. Chu
Orbitofrontal Cortex Pathology in Alzheimer's Disease
Cereb Cortex,
March 1, 2000;
10(3):
243 - 251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Schultz, L. Tremblay, and J. R. Hollerman
Reward Processing in Primate Orbitofrontal Cortex and Basal Ganglia
Cereb Cortex,
March 1, 2000;
10(3):
272 - 283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. D. Volkow and J. S. Fowler
Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex
Cereb Cortex,
March 1, 2000;
10(3):
318 - 325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Porrino and D. Lyons
Orbital and Medial Prefrontal Cortex and Psychostimulant Abuse: Studies in Animal Models
Cereb Cortex,
March 1, 2000;
10(3):
326 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Fudge, J. M. Powers, S. N. Haber, and E. D. Caine
Considering the Role of the Amygdala in Psychotic Illness: A Clinicopathological Correlation
J Neuropsychiatry Clin Neurosci,
November 1, 1998;
10(4):
383 - 394.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. R. Hollerman, L. Tremblay, and W. Schultz
Influence of Reward Expectation on Behavior-Related Neuronal Activity in Primate Striatum
J Neurophysiol,
August 1, 1998;
80(2):
947 - 963.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Shidara, T. G. Aigner, and B. J. Richmond
Neuronal Signals in the Monkey Ventral Striatum Related to Progress through a Predictable Series of Trials
J. Neurosci.,
April 1, 1998;
18(7):
2613 - 2625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Chikama, N. R. McFarland, D. G. Amaral, and S. N. Haber
Insular Cortical Projections to Functional Regions of the Striatum Correlate with Cortical Cytoarchitectonic Organization in the Primate
J. Neurosci.,
December 15, 1997;
17(24):
9686 - 9705.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Levy, H. R. Friedman, L. Davachi, and P. S. Goldman-Rakic
Differential Activation of the Caudate Nucleus in Primates Performing Spatial and Nonspatial Working Memory Tasks
J. Neurosci.,
May 15, 1997;
17(10):
3870 - 3882.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Gusnard, E. Akbudak, G. L. Shulman, and M. E. Raichle
Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function
PNAS,
March 27, 2001;
98(7):
4259 - 4264.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
