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Journal of Neuroscience, Vol 15, 4927-4942, Copyright © 1995 by Society for Neuroscience
Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization
V Avantaggiato, PP Pandolfi, M Ruthardt, N Hawe, D Acampora, PG Pelicci and A Simeone
International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy.
Promyelocyte Leukemia Zinc Finger (PLZF) is a Kruppel-like zinc finger gene
previously identified in a unique case of acute promyelocytic leukemia
(APL) as the counterpart of a reciprocal chromosomal translocation
involving the retinoic acid receptor alpha gene (RAR alpha). PLZF is highly
conserved throughout evolution from yeast to mammals. To elucidate its
role, we isolated the murine PLZF gene and studied its expression during
embryogenesis. PLZF is expressed in an extremely dynamic pattern with
transcripts appearing at E 7.5 in the anterior neuroepithelium and quickly
spreading to the entire neuroectoderm until E 10. At E 8.5, PLZF is
transcribed in most of the endoderm. During mid to late gestation PLZF is
expressed in restricted domains of the developing CNS as well as in
specific organs and body structures. We have focused our attention on the
developing forebrain where PLZF is transcribed in a transverse,
segment-like domain corresponding to the anterior pretectum, in the
alarmost part of the dorsal thalamus, in the epithalamus, and in the
hypothalamus along a defined longitudinal subdomain. Furthermore, PLZF is
expressed in several segmentary boundaries, among them, the zona limitans
intrathalamica. Combined analysis with other regionally restricted genes,
such as Orthopedia and Dlx1, indicates that in the hypothalamus the PLZF
domain is contained within that of Orthopedia and both are complementary to
that of Dlx1. Our data suggest a role for PLZF in the establishment and
maintenance of transverse identities, longitudinal subdomains, and
interneuromeric boundaries, providing additional evidences in favor of the
neuromeric organization of the forebrain.
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