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Journal of Neuroscience, Vol 15, 5088-5097, Copyright © 1995 by Society for Neuroscience
Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
ZL Chen, S Yoshida, K Kato, Y Momota, J Suzuki, T Tanaka, J Ito, H Nishino, S Aimoto and H Kiyama
Department of Structural Cellular Biology, Nara Institute of Science and Technology (NAIST), Japan.
A novel murine cDNA which encodes a protein designated neuropsin was
cloned. Northern and in situ hybridization analyses demonstrated that
neuropsin mRNA is expressed specifically in the limbic system of mouse
brain and is localized at highest concentration in pyramidal neurons of the
hippocampal CA1-3 subfields. Direct hippocampal stimulation and kindling
induced by amygdaloid stimulation caused a significant bilateral change in
neuropsin mRNA level in the hippocampal pyramidal neurons. The
activity-dependent changes and the specific localization indicate that
neuropsin is involved in hippocampal plasticity.
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