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Journal of Neuroscience, Vol 15, 5249-5262, Copyright © 1995 by Society for Neuroscience
Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in rat hippocampal region CA3
ME Hasselmo, E Schnell and E Barkai
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA.
Hippocampal region CA3 contains strong recurrent excitation mediated by
synapses of the longitudinal association fibers. These recurrent excitatory
connections may play a dominant role in determining the information
processing characteristics of this region. However, they result in feedback
dynamics that may cause both runaway excitatory activity and runaway
synaptic modification. Previous models of recurrent excitation have
prevented unbounded activity using biologically unrealistic techniques.
Here, the activation of feedback inhibition is shown to prevent unbounded
activity, allowing stable activity states during recall and learning. In
the model, cholinergic suppression of synaptic transmission at excitatory
feedback synapses is shown to determine the extent to which activity
depends upon new features of the afferent input versus components of
previously stored representations. Experimental work in brain slice
preparations of region CA3 demonstrates the cholinergic suppression of
synaptic transmission in stratum radiatum, which contains synapses of the
longitudinal association fibers.
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