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Journal of Neuroscience, Vol 15, 5297-5307, Copyright © 1995 by Society for Neuroscience
NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum
GB Landwehrmeyer, DG Standaert, CM Testa, JB Penney Jr and AB Young
Neurology Service, Massachusetts General Hospital, Boston 02114, USA.
N-Methyl-D-aspartate (NMDA) receptors are enriched in the neostriatum and
are thought to mediate several actions of glutamate including neuronal
excitability, long-term synaptic plasticity, and excitotoxic injury. NMDA
receptors are assembled from several subunits (NMDAR1, NMDAR2A-D) encoded
by five genes; alternative splicing gives rise to eight isoforms of subunit
NMDAR1. We studied the expression of NMDA receptor subunits in
neurochemically identified striatal neurons of adult rats by in situ
hybridization histochemistry using a double- labeling technique.
Enkephalin-positive projection neurons, somatostatin-positive interneurons,
and cholinergic interneurons each have distinct NMDA receptor subunit
phenotypes. Both populations of striatal interneurons examined express
lower levels of NMDAR1 and NMDAR2B subunit mRNA than enkephalin-positive
neurons. The three striatal cell populations differ also in the presence of
markers for alternatively spliced regions of NMDAR1, suggesting that
interneurons preferentially express NMDAR1 splice forms lacking one
(cholinergic neurons) or both (somatostatin-positive neurons) alternatively
spliced carboxy-terminal regions. In addition, somatostatin- and
cholinergic-, but not enkephalin-positive neurons express NMDAR2D mRNA.
Thus, these striatal cell populations express different NMDAR-subunit mRNA
phenotypes and therefore are likely to display NMDA channels with distinct
pharmacological and physiological properties. Differences in NMDA receptor
expression may contribute to the relative resistance of striatal
interneurons to the neurotoxic effect of NMDA receptor agonists.
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