 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 5379-5388, Copyright © 1995 by Society for Neuroscience
D1 receptors modulate glutamate transmission in the ventral tegmental area
PW Kalivas and P Duffy
Alcohol and Drug Abuse Program, Washington State University, Pullman 99164-6520, USA.
Perfusion of the D1 agonist, SKF-82958, through a microdialysis probe
implanted in the ventral tegmental area produced a dose-dependent increase
in extracellular glutamate and GABA. The increase in extracellular
glutamate occurred at approximately 30x lower dose than the elevation in
GABA. The increase in extracellular glutamate by SKF- 82958 was blocked by
coperfusion of the D1 antagonist, SCH-23390, and was not mimicked by
perfusion of the D2/3 agonist, quinpirole, into the ventral tegmental area.
In contrast, the elevation in extracellular GABA was insensitive to
blockade by SCH-23390. Systemic administration of cocaine (15 mg/kg, i.p.)
produced a rapid elevation in extracellular glutamate lasting for 20 min
that was prevented by pretreating the ventral tegmental area with
SCH-23390. In contrast, acute cocaine produced a reduction in extracellular
GABA content in the ventral tegmental area that was not affected by
SCH-23390. These data indicate that the stimulation of D1 receptors in the
ventral tegmental area increases the release of glutamate and that
increasing extracellular levels of somatodendritic dopamine by systemic
cocaine can mimic this effect.
This article has been cited by other articles:
|
|
|
|
 
E. Argilli, D. R. Sibley, R. C. Malenka, P. M. England, and A. Bonci
Mechanism and Time Course of Cocaine-Induced Long-Term Potentiation in the Ventral Tegmental Area
J. Neurosci.,
September 10, 2008;
28(37):
9092 - 9100.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Aragona, N. A. Cleaveland, G. D. Stuber, J. J. Day, R. M. Carelli, and R. M. Wightman
Preferential Enhancement of Dopamine Transmission within the Nucleus Accumbens Shell by Cocaine Is Attributable to a Direct Increase in Phasic Dopamine Release Events
J. Neurosci.,
August 27, 2008;
28(35):
8821 - 8831.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-Y. Li, C. Xiao, M. Xiong, E. Delphin, and J.-H. Ye
Nanomolar Propofol Stimulates Glutamate Transmission to Dopamine Neurons: A Possible Mechanism of Abuse Potential?
J. Pharmacol. Exp. Ther.,
April 1, 2008;
325(1):
165 - 174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gao and M. E. Wolf
Dopamine Alters AMPA Receptor Synaptic Expression and Subunit Composition in Dopamine Neurons of the Ventral Tegmental Area Cultured with Prefrontal Cortex Neurons
J. Neurosci.,
December 26, 2007;
27(52):
14275 - 14285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Schilstrom, R. Yaka, E. Argilli, N. Suvarna, J. Schumann, B. T. Chen, M. Carman, V. Singh, W. S. Mailliard, D. Ron, et al.
Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors.
J. Neurosci.,
August 15, 2006;
26(33):
8549 - 8558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Wang, Y. Shaham, D. Zitzman, S. Azari, R. A. Wise, and Z.-B. You
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
J. Neurosci.,
June 1, 2005;
25(22):
5389 - 5396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. O'Dell and L. H. Parsons
Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels
J. Pharmacol. Exp. Ther.,
November 1, 2004;
311(2):
711 - 719.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bettler, K. Kaupmann, J. Mosbacher, and M. Gassmann
Molecular Structure and Physiological Functions of GABAB Receptors
Physiol Rev,
July 1, 2004;
84(3):
835 - 867.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Yasumoto, E. Tanaka, G. Hattori, H. Maeda, and H. Higashi
Direct and Indirect Actions of Dopamine on the Membrane Potential in Medium Spiny Neurons of the Mouse Neostriatum
J Neurophysiol,
March 1, 2002;
87(3):
1234 - 1243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Ranaldi and R. A. Wise
Blockade of D1 Dopamine Receptors in the Ventral Tegmental Area Decreases Cocaine Reward: Possible Role for Dendritically Released Dopamine
J. Neurosci.,
August 1, 2001;
21(15):
5841 - 5846.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Fiorillo and J. T. Williams
Selective Inhibition by Adenosine of mGluR IPSPs in Dopamine Neurons After Cocaine Treatment
J Neurophysiol,
March 1, 2000;
83(3):
1307 - 1314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jones and J. A. Kauer
Amphetamine Depresses Excitatory Synaptic Transmission via Serotonin Receptors in the Ventral Tegmental Area
J. Neurosci.,
November 15, 1999;
19(22):
9780 - 9787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. K. Tolliver, L. B. Ho, L. M. Fox, and S. P. Berger
Necessary Role for Ventral Tegmental Area Adenylate Cyclase and Protein Kinase A in Induction of Behavioral Sensitization to Intraventral Tegmental Area Amphetamine
J. Pharmacol. Exp. Ther.,
April 1, 1999;
289(1):
38 - 47.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. Flores, D. Rodaros, and J. Stewart
Long-Lasting Induction of Astrocytic Basic Fibroblast Growth Factor by Repeated Injections of Amphetamine: Blockade by Concurrent Treatment with a Glutamate Antagonist
J. Neurosci.,
November 15, 1998;
18(22):
9547 - 9555.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Darracq, G. Blanc, J. Glowinski, and J.-P. Tassin
Importance of the Noradrenaline-Dopamine Coupling in the Locomotor Activating Effects of D-Amphetamine
J. Neurosci.,
April 1, 1998;
18(7):
2729 - 2739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Umemiya and L. A. Raymond
Dopaminergic Modulation of Excitatory Postsynaptic Currents in Rat Neostriatal Neurons
J Neurophysiol,
September 1, 1997;
78(3):
1248 - 1255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Emmi, H. Rajabi, and J. Stewart
Behavioral and Neurochemical Recovery from Partial 6-Hydroxydopamine Lesions of the Substantia Nigra Is Blocked by Daily Treatment with D1/D5, But Not D2, Dopamine Receptor Antagonists
J. Neurosci.,
May 15, 1997;
17(10):
3840 - 3846.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-F. Zhang, X.-T. Hu, F. J. White, and M. E. Wolf
Increased Responsiveness of Ventral Tegmental Area Dopamine Neurons to Glutamate after Repeated Administration of Cocaine or Amphetamine Is Transient and Selectively Involves AMPA Receptors
J. Pharmacol. Exp. Ther.,
May 1, 1997;
281(2):
699 - 706.
[Abstract]
[Full Text]
|
|
|
|
