QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gabriel, S. M. Articles by Haroutunian, V. Search for Related Content PubMed PubMed Citation Articles by Gabriel, S. M. Articles by Haroutunian, V.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 15, 5526-5534, Copyright © 1995 by Society for Neuroscience

ARTICLE

Alterations in cerebral cortical galanin concentrations following neurotransmitter-specific subcortical lesions in the rat

SM Gabriel, PJ Knott and V Haroutunian
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.

Galanin is associated with multiple projection neurons, and its immunoreactivity in the cerebral cortex may be derived from diverse sources. We investigated the effects of subcortical lesions on cerebral cortical galanin concentrations. Lesions of the anterior noradrenergic bundle (ANB) comparably reduced cerebral cortical galanin and norepinephrine (NE) concentrations. The effects of the ANB lesions on galanin were immediate and became most pronounced 1 week later. Extensive unilateral lesions of the nucleus basalis of Meynert (NBM) decreased galanin concentrations, although not as markedly as after ANB lesions. The NBM lesions had no additional effect in the presence of an ANB lesion. Decreases in cerebral cortical galanin concentrations depended upon the extent and the duration of the NBM lesion and were not as pronounced as the decreases in markers of cholinergic activity. Acute treatments with physostigmine, which inhibit cerebral cortical AChE, had no effect on galanin concentrations. The depletion of galanin following an NBM lesion was most pronounced within hours of the insult, while the depletion of ChAT following the same lesions required several days to develop. Cortical concentrations of galanin and 5-HT increased 1 hr after dorsal raphe nucleus (DRN) lesions and then decreased 7 d later. Six weeks later, galanin concentrations recovered in the cerebral cortex despite the continued depletion of 5-HT. These studies suggest that a substantial portion of cerebral cortical galanin may derive from noradrenergic neurons and may be modulated by cortically- projecting ACh and 5-HT neurons.

This article has been cited by other articles:

				J. K. Robinson Galanin and Cognition Behav Cogn Neurosci Rev, December 1, 2004; 3(4): 222 - 242. [Abstract] [PDF]

				M. Kokaia, K. Holmberg, A. Nanobashvili, Z.-Q. D. Xu, Z. Kokaia, U. Lendahl, S. Hilke, E. Theodorsson, U. Kahl, T. Bartfai, et al. Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin PNAS, October 31, 2001; (2001) 231496298. [Abstract] [Full Text] [PDF]

				Z.-Q. D. Xu, X. Ma, U. Soomets, U. Langel, and T. Hokfelt Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selective receptor on hippocampal CA3 pyramidal neurons PNAS, December 7, 1999; 96(25): 14583 - 14587. [Abstract] [Full Text] [PDF]

				M. Kokaia, K. Holmberg, A. Nanobashvili, Z.-Q. D. Xu, Z. Kokaia, U. Lendahl, S. Hilke, E. Theodorsson, U. Kahl, T. Bartfai, et al. Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin PNAS, November 20, 2001; 98(24): 14006 - 14011. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help