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Journal of Neuroscience, Vol 15, 5560-5573, Copyright © 1995 by Society for Neuroscience
Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP
T Hosokawa, DA Rusakov, TV Bliss and A Fine
Department of Physiology and Biophysics, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada.
Using confocal microscopy in conjunction with microdrop application of Dil,
we have imaged and measured individual dendritic spines of living
hippocampal CA1 pyramidal neurons in acute brain slices, before and
approximately 3 hr after induction of long-term potentiation by chemical
means. Statistical analysis of changes in the length of individual spines,
and comparison with results of Monte Carlo simulations, suggests that two
forms of structural change occur in chemically induced long-term
potentiation: growth of a subpopulation of small spines, and angular
displacement of spines. These changes could provide a structural basis for
the expression of long-term potentiation.
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