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Journal of Neuroscience, Vol 15, 5727-5738, Copyright © 1995 by Society for Neuroscience
Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation
GE Lyons, BK Micales, J Schwarz, JF Martin and EN Olson
Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA.
Members of the myocyte enhancer factor 2 (MEF2) gene family are expressed
in a dynamic pattern during development of the CNS of pre- and postnatal
mice. The four MEF2 genes, Mef2A, -B, -C, -D, encode transcription factors
belonging to the MADS (MCM1-agamous-deficiens- serum response factor)
superfamily of DNA binding proteins. MEF2 factors have previously been
shown to be positive regulators of gene expression in terminally
differentiated muscle cells. To begin to determine the role of MEF2 factors
in CNS development, we used in situ hybridization with gene-specific cRNA
probes to define the expression patterns of each of the four Mef2 mRNAs in
the developing and mature mouse CNS. Mef2C mRNA was first detected in a
ventral portion of the telencephalon at 11.5 d postcoitum (p.c.). By 13.5 d
p.c., each of the four Mef2 genes were expressed in overlapping yet
distinct patterns in regions of the frontal cortex, midbrain, thalamus,
hippocampus, and hindbrain. Temporal and spatial patterns of embryonic Mef2
gene expression appeared to follow gradients of neuron maturation and
suggested that the onset of Mef2 gene expression coincides with withdrawal
from the cell cycle and initiation of neuronal differentiation. This
correlation is particularly striking for Purkinje cells in the cerebellum.
Since the molecular mechanisms that regulate neuron differentiation are
unknown, we propose that the MEF2 factors are likely to play an important
role in this process.
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134(23):
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|
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|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
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|
|
|
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|
|
|
|
|
|
|
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January 5, 1999;
126(10):
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[Abstract]
[PDF]
|
|
|
|
|
|
|
I. S. Skerjanc, H. Petropoulos, A. G. Ridgeway, and S. Wilton
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December 25, 1998;
273(52):
34904 - 34910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Satyaraj and U. Storb
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J. Immunol.,
November 1, 1998;
161(9):
4795 - 4802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Krainc, G. Bai, S.-i. Okamoto, M. Carles, J. W. Kusiak, R. N. Brent, and S. A. Lipton
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J. Biol. Chem.,
October 2, 1998;
273(40):
26218 - 26224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Roztocil, L. Matter-Sadzinski, M. Gomez, M. Ballivet, and J.-M. Matter
Functional Properties of the Neuronal Nicotinic Acetylcholine Receptor beta 3 Promoter in the Developing Central Nervous System
J. Biol. Chem.,
June 12, 1998;
273(24):
15131 - 15137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q Lin, J Lu, H Yanagisawa, R Webb, G. Lyons, J. Richardson, and E. Olson
Requirement of the MADS-box transcription factor MEF2C for vascular development
Development,
January 11, 1998;
125(22):
4565 - 4574.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P Ruiz-Lozano, S. Smith, G Perkins, S. Kubalak, G. Boss, H. Sucov, R. Evans, and K. Chien
Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos
Development,
January 2, 1998;
125(3):
533 - 544.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. J. Yaworsky, D. P. Gardner, and C. Kappen
Transgenic Analyses Reveal Developmentally Regulated Neuron- and Muscle-specific Elements in the Murine Neurofilament Light Chain Gene Promoter
J. Biol. Chem.,
October 3, 1997;
272(40):
25112 - 25120.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Lin, J. Schwarz, C. Bucana, and E. N. Olson
Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C
Science,
May 30, 1997;
276(5317):
1404 - 1407.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y.-T. Yu and Y. T. Yu
Distinct Domains of Myocyte Enhancer Binding Factor-2A Determining Nuclear Localization and Cell Type-specific Transcriptional Activity
J. Biol. Chem.,
October 4, 1996;
271(40):
24675 - 24683.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Mao and B. Nadal-Ginard
Functional and Physical Interactions between Mammalian Achaete-Scute Homolog 1and Myocyte Enhancer Factor 2A
J. Biol. Chem.,
June 14, 1996;
271(24):
14371 - 14375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.G. Edwards, G.E. Lyons, B.K. Micales, A. Malhotra, S. Factor, and L.A. Leinwand
Cardiomyopathy in Transgenic myf5 Mice
Circ. Res.,
March 1, 1996;
78(3):
379 - 387.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. B. Firulli, J. M. Miano, W. Bi, A. D. Johnson, W. Casscells, E. N. Olson, and J. J. Schwarz
Myocyte Enhancer Binding Factor-2 Expression and Activity in Vascular Smooth Muscle Cells : Association With the Activated Phenotype
Circ. Res.,
February 1, 1996;
78(2):
196 - 204.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Matsuo, J. K. Stauffer, R. L. Walker, P. Meltzer, and C. J. Thiele
Structure and Promoter Analysis of the Human unc-33-like Phosphoprotein Gene. E-BOX REQUIRED FOR MAXIMAL EXPRESSION IN NEUROBLASTOMA AND MYOBLASTS
J. Biol. Chem.,
May 26, 2000;
275(22):
16560 - 16568.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Allen, M. Xu, C. Zeng, S. A. Tobet, and M. E. Wierman
Myocyte Enhancer Factors-2B and -2C Are Required for Adhesion Related Kinase Repression of Neuronal Gonadotropin Releasing Hormone Gene Expression
J. Biol. Chem.,
December 8, 2000;
275(50):
39662 - 39670.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Zhang, T. A. McKinsey, J.-r. Lu, and E. N. Olson
Association of COOH-terminal-binding Protein (CtBP) and MEF2-interacting Transcription Repressor (MITR) Contributes to Transcriptional Repression of the MEF2 Transcription Factor
J. Biol. Chem.,
January 5, 2001;
276(1):
35 - 39.
[Abstract]
[Full Text]
[PDF]
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PNAS,
June 20, 2000;
97(13):
7561 - 7566.
[Abstract]
[Full Text]
[PDF]
|
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