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Journal of Neuroscience, Vol 15, 5739-5752, Copyright © 1995 by Society for Neuroscience
Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei
DA McCormick, F Trent and AS Ramoa
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Extracellular and intracellular recordings from slices of ferret dorsal
lateral geniculate nucleus (LGNd) at postnatal ages P10-53 were performed
to examine the postnatal development of spindle waves and the ability of
block of GABAA receptors to alter these spindle waves into a slower,
synchronous oscillation. As in prior studies in the adult, intracellular
and extracellular recordings at ages P33-53 revealed robust spindle waves
to be present in both the LGNd and perigeniculate nucleus (PGN).
Intracellular recordings from thalamocortical relay cells in the A-laminae
of the LGNd revealed that these cells received repetitive inhibitory
postsynaptic potentials (IPSPs) at 6-9 Hz during the generation of spindle
waves, and generated rebound low threshold Ca2+ spikes and bursts of 2-6
action potentials following each second or third IPSP. Intracellular
recordings from the GABAergic neurons of the PGN at P33-53 revealed
barrages of EPSPs that activated low threshold Ca2+ spikes and high
frequency burst discharges of 2-10 action potentials during spindle wave
generation. In contrast, full spindle waves were absent at ages prior to
approximately P22 and spindle waves between the ages of P26 and
approximately P30 were relatively weak and associated with only one or two
action potentials per burst in both PGN neurons and LGNd relay cells. Bath
application of the GABAA antagonist bicuculline methiodide at P41-53
resulted in a conversion of normal spindle waves into a marked 2-4 Hz
oscillation in which the action potential firing of both thalamocortical
relay and PGN neurons was greatly increased. In contrast, block of GABAA
receptors prior to age P39 did not result in the generation of the slowed,
2-4 Hz network oscillation. Investigation of the electrophysiological
properties of PGN neurons revealed that the postnatal development of
spindle waves and bicuculline-induced slow oscillations were associated
with an increase in the ability of PGN neurons to generate high frequency
bursts of action potentials, suggesting that these changes in
electrophysiological properties may contribute to the late development of
synchronized oscillations in the ferret LGNd.
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