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Journal of Neuroscience, Vol 15, 5779-5788, Copyright © 1995 by Society for Neuroscience
Rats with fimbria-fornix lesions display a place response in a swimming pool: a dissociation between getting there and knowing where
IQ Whishaw, JC Cassel and LE Jarrad
Department of Psychology, University of Lethbridge, Alberta, Canada.
Some theories of hippocampal formation function postulate that it is
involved in using the relationships between distal cues for spatial
navigation. That rats with damage to the hippocampal formation are impaired
in learning place responses of escaping to a platform hidden just below the
surface of the water of a swimming pool, supports this view. Using rats
with fimbria-fornix (FF) lesions, we examined whether their impairment is
related to an inability to learn how to reach the platform as opposed to
learning its location. In a first experiment, the FF rats were impaired in
learning to swim to a hidden platform but could swim to a visible platform.
In a second experiment, after being pretrained to swim to a visible
platform, the FF rats swam to, paused, and searched the vicinity of the
platform's previous location when it was removed. This finding showed that
the FF rats expected to find the platform at that location. Additional
tests confirmed that they had learned a place response. Despite having
acquired a place response, they still could not acquire new place responses
when only the hidden platform training procedure was used. Thus, these
results in dissociating the processes of "getting there" and "knowing
where" suggest that the FF rats' impairment may be in some process of
motoric control, such as path integration, rather than in learning the
location of the platform in relation to ambient cues. The results are
discussed in relation to relevant theories of hippocampal function.
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