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Journal of Neuroscience, Vol 15, 5810-5819, Copyright © 1995 by Society for Neuroscience
Seizures and failures in the giant fiber pathway of Drosophila bang- sensitive paralytic mutants
P Pavlidis and MA Tanouye
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
Drosophila bang-sensitive paralytic mutants suffer from hyperactivity and
paralysis following a mechanical shock; after recovery from paralysis, they
cannot be paralyzed for a refractory period lasting up to 1 hr. Previously,
we have shown that in easily shocked (eas), a typical bang-sensitive
mutant, electrical shocks delivered to the brain cause seizure-like
activity in the dorsal longitudinal flight motor neurons (DLMmns), and
failure of giant fiber (GF) stimulation to evoke DLM potentials via the
escape response pathway (Pavlidis et al., 1994). Here, we show that seizure
and failure in the GF pathway with a refractory period is common to all six
members of the bang-sensitive class. This syndrome was not found in any of
eight other excitability mutants, including those affecting voltage-gated
sodium or potassium- channel function. We show that failure occurs at the
synapse between a peripherally synapsing interneuron (PSI) and the DLMmns,
while the DLMmn-DLM neuromuscular junctions remain functional.
Additionally, failure occurs in all other GF pathway-activated muscles.
Failures occurred without seizures in the tergotrochanteral jump muscle
(TTM), as was also found in approximately 10% of DLM tests, suggesting that
seizures and failures may be independent events. This hypothesis is
supported by the finding that, in double mutant combination with mlenapts,
which suppresses behavioral bang sensitivity, DLM failures, but not
seizures, were reduced.
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