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Journal of Neuroscience, Vol 15, 6058-6068, Copyright © 1995 by Society for Neuroscience
Early ontogeny of the secondary proliferative population of the embryonic murine cerebral wall
T Takahashi, RS Nowakowski and VS Caviness Jr
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
The present report is an analysis of the proliferative behavior of the
secondary proliferative population (SPP) of the dorsomedial region of the
embryonic mouse cerebral wall. It is based upon experiments undertaken on
embryonic days 14-16 (E14-E16) and exploits methods in which proliferative
cells are labeled in S phase with either or both bromodeoxyuridine and
tritiated thymidine. The SPP, which arises from the PVE by E13, is
principally the progenitor population to the neuroglial population of the
mature neocortex and subjacent cerebral wall. By the end of E14 the SPP
comes to be distributed diffusely from the outer margin of the ventricular
zone throughout subventricular zone and intermediate zone. The length of
the cell cycle of the SPP is constant at approximately 15 hr throughout
this interval; thus, this population undergoes 1.6 cell cycles/24 hr or 3.2
cycles in the course of the 48 hr period, E14-E16. Over this 48 hr period,
the SPP increases from 11% to 35% of the total proliferative population of
the dorsomedial cerebral wall. The absolute size of the SPP increases
nearly sixfold. With these values taken together it may be estimated that
approximately 87% of postmitotic cells of the SPP reenter S phase after
each cell division in this interval which means that only approximately 13%
of the proliferative population exits the cycle. These findings illustrate
the massive expansion of the SPP antecedent to the explosive diffusion of
glial cells through the neocortex and subjacent cerebral wall as neuronal
migration comes to completion and neocortical growth and differentiation
accelerate.
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