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Journal of Neuroscience, Vol 16, 169-185, Copyright © 1996 by Society for Neuroscience
In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons
A Destexhe, D Contreras, M Steriade, TJ Sejnowski and JR Huguenard
Howard Hughes Medical Institute, Salk Institute for Biological Studies, Computational Neurobiology Laboratory, La Jolla, California 92037, USA.
Thalamic reticular (RE) neurons are involved in the genesis of synchronized
thalamocortical oscillations, which depend in part on their complex
bursting properties. We have investigated the intrinsic properties of RE
cells using computational models based on morphological and
electrophysiological data. Simulations of a reconstructed RE cells were
compared directly with recordings from the same cell to obtain precise
values for the passive parameters. In a first series of experiments, the
low-threshold calcium current (I(Ts)) was studied via voltage clamp in
acutely dissociated RE cells that lack most of their dendrites. Simulations
based on a cell with truncated dendrites and Hodgkin-Huxley kinetics
reproduced these recordings with a relatively low density of I(Ts). In a
second series of experiments, voltage-clamp recordings obtained in intact
RE cells in slices showed a higher amplitude and slower kinetics of I(Ts).
These properties could be reproduced from the reconstructed cell model
assuming higher densities of I(Ts) in distal dendrites. In a third series
of experiments, current-clamp recordings were obtained on RE cells in vivo.
The marked differences with in vitro recordings could be reconciled by
simulating synaptic bombardment in the dendrites of RE cells, but only if
they contained high distal densities of I(Ts). In addition, simpler models
with as few as three compartments could reproduce the same behavior
assuming dendritic I(Ts). These models and experiments show how intrinsic
bursting properties of RE cells, as recorded in vivo and in vitro, may be
explained by dendritic calcium currents.
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