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Journal of Neuroscience, Vol 16, 307-312, Copyright © 1996 by Society for Neuroscience
A dendritic GABAA-mediated IPSP regulates facilitation of NMDA-mediated responses to burst stimulation of afferent fibers in piriform cortex
ED Kanter, A Kapur and LB Haberly
Neuroscience Training Program, University of Wisconsin, Madison 53706, USA.
Studies in a number of cortical systems have shown that the NMDA component
of the EPSP is strongly regulated by GABAA-mediated inhibition. The present
study explored the possibility that specificity in inhibitory circuitry
could allow such regulation to occur during normal function without
increasing the propensity for epileptiform bursting, which occurs with
indiscriminate GABAA blockade. Specifically, the hypothesis was tested that
a dendritic GABAA-mediated IPSP is present which strongly modulates the
NMDA component and can be activated independently of the somatic IPSP. The
experiments were performed on slices of piriform cortex in which the NMDA
component of the EPSP was pharmacologically isolated by bath-applied 6,7-
dinitroquinoxaline-2,3-dione. A facilitation of NMDA responses to burst
stimulation of afferent fibers is described, which required GABAA blockade
and served as an assay for the presence of a functionally significant GABAA
input. When bicuculline was applied focally in the somatic region, the
feedback IPSP was blocked with little or no increase in the NMDA component
of the response to burst stimulation of afferent fibers. In contrast, when
bicuculline was applied focally in the dendritic region, the NMDA-mediated
response to burst stimulation was facilitated with minimal effect on the
somatic IPSP, confirming the hypothesis.
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