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Journal of Neuroscience, Vol 16, 354-372, Copyright © 1996 by Society for Neuroscience
Hippocampal ensemble activity during spatial delayed-nonmatch-to-sample performance in rats
SA Deadwyler, T Bunn and RE Hampson
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA.
Multiple-cell recording from specially designed arrays of microwire
electrodes allowed analysis of anatomically defined ensemble activity from
10 different locations within the hippocampus of rats (n = 7) performing a
two-lever operant version of a spatial delayed-nonmatch-to- sample task
(DNMS). Application of population analysis procedures to ensembles of
single-neuron activity within the CA1 and CA3 fields revealed firing
patterns related to task-relevant events within a DNMS trial. The patterns
were extracted via a canonical discriminant analysis in the form of "roots"
that represented sources of variance in firing within the ensemble, such as
phase of the task (Sample or Nonmatch), spatial position of the lever press
response (left or right), and correct versus error trials. Comparison of
the ensemble firing on correct versus error trials revealed important
insight into ensemble information encoding, such as "miscoding" of the
response position and lack of distinct encoding of the response in the
Sample phase, which became increasingly vulnerable to error as a function
of the duration of delay interval. The extracted discriminant scores were
reflective of multiple representations within ensembles and suggested that
"conjunctions" of task-relevant features could be represented effectively
by small numbers of hippocampal neurons. The findings support the long-held
supposition that hippocampal neurons play a critical role in the encoding
and retrieval of information in recognition memory tasks.
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