 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
Volume 16, Number 10, Issue of May 15, 1996 pp. 3296-3310
Copyright ©1996 Society for NeuroscienceBEN As a Presumptive Target Recognition Molecule during the Development of the Olivocerebellar System
Received Jan. 19, 1996; revised Feb. 23, 1996; accepted Feb. 29, 1996.
Alain Chédotal1, Olivier Pourquié2, Frédéric Ezan1, Hélène San Clemente2, and Constantino Sotelo1 1 Institut National de la Santé et de la Recherche Médicale, Neuromorphologie, Développement, Evolution, Hôpital de la Salpêtrière, 75651 Paris Cedex 13, France, and 2 Institut d'Embryologie Cellulaire et Moléculaire du Centre National de la Recherche Scientifique et du Collège de France, 94736 Nogent-sur-Marne Cedex, France
It has been shown previously that in the chick embryo the cell adhesion molecule BEN/SC1/DM-GRASP is expressed by neurons in the inferior olive (IO) and by their terminal axonal arbors in the cerebellar cortex, the climbing fibers (). Here, new information on the expression of BEN during the formation of the olivocerebellar projection adds the important notion that BEN is also expressed by the cerebellar targets of inferior olivary axons, Purkinje cells (PCs) and deep nuclear neurons. This expression is transient, starting at E7-E8 and vanishing shortly after hatching. More importantly, BEN expression is restricted to precise subsets of IO neurons and PCs. In the cerebellar cortex, BEN-immunoreactive (BEN-IR) structures are not found randomly but are distributed according to a reproducible pattern of parasagittal stripes. A maximum of four distinct sagittal stripes is found in each lobule, along the whole rostrocaudal extent of the cerebellum. Moreover, BEN-expressing stripes belong to two classes; one contains BEN-IR climbing fibers terminating on BEN-IR PCs and the other, more frequent class is solely composed of BEN-IR climbing fibers. Organotypic cultures of isolated cerebella have shown that the expression of BEN in the IO and in the cerebellum arise independently, probably because of an intrinsic developmental program. Thus, the cell adhesion molecule BEN meets all criteria for a recognition molecule involved in the formation of the olivocerebellar projection.
Key words: inferior olive; Purkinje cell; climbing fiber; chick; cell adhesion; projection map formation
This article has been cited by other articles:
K. Thelen, T. Georg, S. Bertuch, P. Zelina, and G. E. Pollerberg
Ubiquitination and Endocytosis of Cell Adhesion Molecule DM-GRASP Regulate Its Cell Surface Presence and Affect Its Role for Axon Navigation
J. Biol. Chem., November 21, 2008; 283(47): 32792 - 32801.
[Abstract] [Full Text] [PDF]
T. Di Meglio, K. T. Nguyen-Ba-Charvet, M. Tessier-Lavigne, C. Sotelo, and A. Chedotal
Molecular Mechanisms Controlling Midline Crossing by Precerebellar Neurons
J. Neurosci., June 18, 2008; 28(25): 6285 - 6294.
[Abstract] [Full Text] [PDF]
S. Backer, M. Hidalgo-Sanchez, N. Offner, E. Portales-Casamar, A. Debant, P. Fort, C. Gauthier-Rouviere, and E. Bloch-Gallego
Trio Controls the Mature Organization of Neuronal Clusters in the Hindbrain
J. Neurosci., September 26, 2007; 27(39): 10323 - 10332.
[Abstract] [Full Text] [PDF]
K. Nishida, J. G. Flanagan, and M. Nakamoto
Domain-specific olivocerebellar projection regulated by the EphA-ephrin-A interaction
Development, March 14, 2003; 129(24): 5647 - 5658.
[Abstract] [Full Text] [PDF]
I. Sugihara, H.-S. Wu, and Y. Shinoda
The Entire Trajectories of Single Olivocerebellar Axons in the Cerebellar Cortex and their Contribution to Cerebellar Compartmentalization
J. Neurosci., October 1, 2001; 21(19): 7715 - 7723.
[Abstract] [Full Text] [PDF]
S. D. Karam, R. C. Burrows, C. Logan, S. Koblar, E. B. Pasquale, and M. Bothwell
Eph Receptors and Ephrins in the Developing Chick Cerebellum: Relationship to Sagittal Patterning and Granule Cell Migration
J. Neurosci., September 1, 2000; 20(17): 6488 - 6500.
[Abstract] [Full Text] [PDF]
I. Sugihara, Y. Bailly, and J. Mariani
Olivocerebellar Climbing Fibers in the Granuloprival Cerebellum: Morphological Study of Individual Axonal Projections in the X-Irradiated Rat
J. Neurosci., May 15, 2000; 20(10): 3745 - 3760.
[Abstract] [Full Text] [PDF]
S. L. Baader, M. W. Vogel, S. Sanlioglu, X. Zhang, and J. Oberdick
Selective Disruption of "Late Onset" Sagittal Banding Patterns by Ectopic Expression of Engrailed-2 in Cerebellar Purkinje Cells
J. Neurosci., July 1, 1999; 19(13): 5370 - 5379.
[Abstract] [Full Text] [PDF]
C. Vaillant, M. Didier-Bazes, A. Hutter, M.-F. Belin, and N. Thomasset
Spatiotemporal Expression Patterns of Metalloproteinases and Their Inhibitors in the Postnatal Developing Rat Cerebellum
J. Neurosci., June 15, 1999; 19(12): 4994 - 5004.
[Abstract] [Full Text] [PDF]
E. Bloch-Gallego, F. Ezan, M. Tessier-Lavigne, and C. Sotelo
Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons
J. Neurosci., June 1, 1999; 19(11): 4407 - 4420.
[Abstract] [Full Text] [PDF]
S. A. Rabacchi, J. M. Solowska, B. Kruk, Y. Luo, J. A. Raper, and D. H. Baird
Collapsin-1/Semaphorin-III/D Is Regulated Developmentally in Purkinje Cells and Collapses Pontocerebellar Mossy Fiber Neuronal Growth Cones
J. Neurosci., June 1, 1999; 19(11): 4437 - 4448.
[Abstract] [Full Text] [PDF]
J. A. Encinas, K. Kikuchi, A. Chedotal, F. de Castro, C. S. Goodman, and T. Kimura
Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family
PNAS, March 2, 1999; 96(5): 2491 - 2496.
[Abstract] [Full Text] [PDF]
C. Fournier-Thibault, O. Pourquie, T. Rouaud, and N. M. Le Douarin
BEN/SC1/DM-GRASP Expression during Neuromuscular Development: a Cell Adhesion Molecule Regulated by Innervation
J. Neurosci., February 15, 1999; 19(4): 1382 - 1392.
[Abstract] [Full Text] [PDF]
J. C. Lin and C. L. Cepko
Granule Cell Raphes and Parasagittal Domains of Purkinje Cells: Complementary Patterns in the Developing Chick Cerebellum
J. Neurosci., November 15, 1998; 18(22): 9342 - 9353.
[Abstract] [Full Text] [PDF]
C. Logan, R. J. T. Wingate, I. J. McKay, and A. Lumsden
Tlx-1 and Tlx-3 Homeobox Gene Expression in Cranial Sensory Ganglia and Hindbrain of the Chick Embryo: Markers of Patterned Connectivity
J. Neurosci., July 15, 1998; 18(14): 5389 - 5402.
[Abstract] [Full Text] [PDF]
J Adam, A Myat, I Le Roux, M Eddison, D Henrique, D Ish-Horowicz, and J Lewis
Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: parallels with Drosophila sense-organ development
Development, January 12, 1998; 125(23): 4645 - 4654.
[Abstract] [PDF]
A Varela-Echavarria and S Guthrie
Molecules making waves in axon guidance.
Genes & Dev., March 1, 1997; 11(5): 545 - 557.
[PDF]
A Chedotal, E Bloch-Gallego, and C Sotelo
The embryonic cerebellum contains topographic cues that guide developing inferior olivary axons
Development, January 2, 1997; 124(4): 861 - 870.
[Abstract] [PDF]
M.-C. Tiveron, M.-R. Hirsch, and J.-F. Brunet
The Expression Pattern of the Transcription Factor Phox2 Delineates Synaptic Pathways of the Autonomic Nervous System
J. Neurosci., December 1, 1996; 16(23): 7649 - 7660.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|