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Volume 16, Number 10,
Issue of May 15, 1996
pp. 3397-3411
Copyright ©1996 Society for Neuroscience
Interneurons Containing Calretinin Are Specialized to Control
Other Interneurons in the Rat Hippocampus
Received Dec. 6, 1995; revised Feb. 20, 1996; accepted Feb. 23, 1996.
Attila I. Gulyás,
Norbert Hájos, and
Tamás F. Freund
Institute of Experimental Medicine, Hungarian Academy of Sciences,
Budapest H-1450, Hungary
Spine-free calretinin-immunoreactive (CR-IR) interneurons form a
subpopulation of GABAergic cells in the rat hippocampus. A
characteristic feature of these cells located in all areas and
layersis the frequent dendro-dendritic and axo-dendritic contacts
they form with each other. In this study we examined in detail the
connectivity of these neurons by reconstructing their dendritic and
axonal arbor and by identifying their postsynaptic targets.
Radially running dendrites of CR-IR cells, located in different layers,
intermingled into long braids. An average cell was in contact with
dendrites of three to seven other CR-IR cells. Reconstruction of the
dendritic trees from six consecutive sections demonstrated that at
least 15 cells may participate in a dendro-dendritically connected
cluster. Electron microscopical examination revealed that regularly
spaced zonula adherentia connect the touching dendrites.
The postsynaptic targets of CR-IR neurons have been examined using
postembedding immunogold staining for GABA. CR-containing
GABA-immunoreactive axons of local origin formed multiple symmetrical
synaptic contacts (two to five) exclusively on GABAergic dendrites
(CR-negative as well as CR-positive). Two to 10 CR-IR axons may
converge onto a single CR-IR neuron, often from cells belonging to the
same dendro-dendritically connected cluster. Using double
immunocytochemistry, CR-IR cells were shown to heavily innervate
calbindin D28k-containing interneurons and
VIP-containing basket cells but avoided the parvalbumin-containing
basket and axo-axonic cells.
The unique connectivity of CR-IR cells may enable them to play a
crucial role in the generation of synchronous, rhythmic hippocampal
activity by controlling other interneurons terminating on different
dendritic and somatic compartments of principal cells.
Key words:
GABA;
nonpyramidal cells;
disinhibition;
inhibition;
dendro-dendritic contacts;
oscillation;
gap junction;
VIP;
cholecystokinin
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