 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
Volume 16, Number 11, Issue of June 1, 1996 pp. 3652-3660
Copyright ©1996 Society for NeuroscienceActions of Endogenous Opioids on NMDA Receptor-Independent Long-Term Potentiation in Area CA3 of the Hippocampus
Received Jan. 11, 1996; revised March 11, 1996; accepted March 13, 1996.
Stephen H. Williams and Daniel Johnston Department of Neurology and Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
The opioid peptides represent a major class of neurotransmitter in the vertebrate nervous system and are prevalent in the hippocampus. There is considerable interest in the physiological function of the opioids contained in the mossy fiber pathway. The release of opioids from mossy fibers shows a strong frequency dependence. Long-term potentiation (LTP) at this synapse, an NMDA receptor-independent form of LTP, also depends on high-frequency synaptic activity, and this has led to speculation that endogenous opioids may be a critical factor in LTP induction. Previous reports using extracellular recordings have provided evidence for and against a role for opioids in mossy fiber LTP. Using single-cell recording techniques, we have tested the hypothesis that endogenous opioids are required for mossy fiber LTP induction. We recorded from a defined population of synapses that had EPSCs with fast rise times, short latencies, and monophasic decays, consistent with a proximally terminating synapse. The opioid antagonist naloxone prevented mossy fiber LTP in the rat, but had no effect on the commissural/associational system, a nonopioid-containing pathway. The action of naloxone was not mediated through disinhibition because GABAA receptors were pharmacologically blocked in these experiments. We also tested the hypothesis that variations in postsynaptic receptor subtype distribution between species might explain previous controversies regarding the role of endogenous opioids. In contrast to the rat, LTP of the mossy fiber field potential in guinea pig was not blocked by naloxone. Our data suggest that opioids may be the presynaptically released, frequency-dependent, associative factor for mossy fiber LTP induction.
Key words: LTP; mossy fiber; hippocampus; opioid; naloxone; CA3; NMDA-independent; species differences
This article has been cited by other articles:
W. J. Meilandt, G.-Q. Yu, J. Chin, E. D. Roberson, J. J. Palop, T. Wu, K. Scearce-Levie, and L. Mucke
Enkephalin Elevations Contribute to Neuronal and Behavioral Impairments in a Transgenic Mouse Model of Alzheimer's Disease
J. Neurosci., May 7, 2008; 28(19): 5007 - 5017.
[Abstract] [Full Text] [PDF]
K. J. Thompson, M. L. Mata, J. E. Orfila, E. J. Barea-Rodriguez, and J. L. Martinez Jr.
Metabotropic Glutamate Receptor Antagonist AIDA Blocks Induction of Mossy Fiber-CA3 LTP In Vivo
J Neurophysiol, May 1, 2005; 93(5): 2668 - 2673.
[Abstract] [Full Text] [PDF]
J. Wang, M. F. Yeckel, D. Johnston, and R. S. Zucker
Photolysis of Postsynaptic Caged Ca2+ Can Potentiate and Depress Mossy Fiber Synaptic Responses in Rat Hippocampal CA3 Pyramidal Neurons
J Neurophysiol, April 1, 2004; 91(4): 1596 - 1607.
[Abstract] [Full Text] [PDF]
W. J. Meilandt, E. Barea-Rodriguez, S. A. K. Harvey, and J. L. Martinez Jr
Role of Hippocampal CA3 {micro}-Opioid Receptors in Spatial Learning and Memory
J. Neurosci., March 24, 2004; 24(12): 2953 - 2962.
[Abstract] [Full Text] [PDF]
S. Lei, K. A. Pelkey, L. Topolnik, P. Congar, J.-C. Lacaille, and C. J. McBain
Depolarization-Induced Long-Term Depression at Hippocampal Mossy Fiber-CA3 Pyramidal Neuron Synapses
J. Neurosci., October 29, 2003; 23(30): 9786 - 9795.
[Abstract] [Full Text] [PDF]
J. Bischofberger, J. R. P. Geiger, and P. Jonas
Timing and Efficacy of Ca2+ Channel Activation in Hippocampal Mossy Fiber Boutons
J. Neurosci., December 15, 2002; 22(24): 10593 - 10602.
[Abstract] [Full Text] [PDF]
Q.-Q. Sun, J. R. Huguenard, and D. A. Prince
Somatostatin Inhibits Thalamic Network Oscillations In Vitro: Actions on the GABAergic Neurons of the Reticular Nucleus
J. Neurosci., July 1, 2002; 22(13): 5374 - 5386.
[Abstract] [Full Text] [PDF]
J. M. Harrison, R. G. Allen, M. J. Pellegrino, J. T. Williams, and O. J. Manzoni
Chronic Morphine Treatment Alters Endogenous Opioid Control of Hippocampal Mossy Fiber Synaptic Transmission
J Neurophysiol, May 1, 2002; 87(5): 2464 - 2470.
[Abstract] [Full Text] [PDF]
G. W. Terman, C. T. Drake, M. L. Simmons, T. A. Milner, and C. Chavkin
Opioid Modulation of Recurrent Excitation in the Hippocampal Dentate Gyrus
J. Neurosci., June 15, 2000; 20(12): 4379 - 4388.
[Abstract] [Full Text] [PDF]
H. Ikeda, T. Asai, M. Randic, and K. Murase
Robust Suppression of Afferent-Induced Excitation in the Rat Spinal Dorsal Horn After Conditioning Low-Frequency Stimulation
J Neurophysiol, October 1, 1999; 82(4): 1957 - 1964.
[Abstract] [Full Text] [PDF]
L. P. Baker, M. D. Nielsen, S. Impey, B. M. Hacker, S. W. Poser, M. Y. M. Chan, and D. R. Storm
Regulation and Immunohistochemical Localization of beta gamma -Stimulated Adenylyl Cyclases in Mouse Hippocampus
J. Neurosci., January 1, 1999; 19(1): 180 - 192.
[Abstract] [Full Text] [PDF]
A. Kapur, M. F. Yeckel, R. Gray, and D. Johnston
L-Type Calcium Channels Are Required for One Form of Hippocampal Mossy Fiber LTP
J Neurophysiol, April 1, 1998; 79(4): 2181 - 2190.
[Abstract] [Full Text] [PDF]
C. R. Bramham and J. M. Sarvey
Endogenous Activation of µ and delta -1 Opioid Receptors Is Required for Long-Term Potentiation Induction in the Lateral Perforant Path: Dependence on GABAergic Inhibition
J. Neurosci., December 15, 1996; 16(24): 8123 - 8131.
[Abstract] [Full Text] [PDF]
N N Urban, D A Henze, D A Lewis, and G Barrionuevo
Properties of LTP induction in the CA3 region of the primate hippocampus.
Learn. Mem., January 1, 1996; 3(2-3): 86 - 95.
[Abstract] [PDF]
|
|
|
|
 |
|