 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 16, Number 12, Issue of June 15, 1996 pp. 3877-3886
Copyright ©1996 Society for NeuroscienceHomeostasis of Synaptic Transmission in Drosophila with Genetically Altered Nerve Terminal Morphology
Received Dec. 15, 1995; revised March 21, 1996; accepted March 25, 1996.
Bryan A. Stewart1, Christoph M. Schuster2, Corey S. Goodman2, and Harold L. Atwood1 1 Department of Physiology, University of Toronto, Toronto, Ontario, Canada, M5S 1A8, and 2 Howard Hughes Medical Institute, Department of Cellular and Molecular Biology, University of California, Berkeley, California 94720
We present a new test of the hypothesis that synaptic strength is directly related to nerve terminal morphology through analysis of synaptic transmission at Drosophila neuromuscular junctions with a genetically reduced number of nerve terminal varicosities. Synaptic transmission would decrease in target cells with fewer varicosities if there is a relationship between the number of varicosities and the strength of synaptic transmission. Animals that have an extreme hypomorphic allele of the gene for the cell adhesion molecule Fasciclin II possess fewer synapse-bearing nerve terminal varicosities; nevertheless, synaptic strength is maintained at a normal level for the muscle cell as a whole. Fewer failures of neurotransmitter release and larger excitatory junction potentials from individual varicosities, as well as more frequent spontaneous release and larger quantal units, provide evidence for enhancement of transmitter release from varicosities in the mutant. Ultrastructural analysis reveals that mutant nerve terminals have bigger synapses with more active zones per synapse, indicating that synaptic enlargement and an accompanying increase in synaptic complexity provide for more transmitter release at mutant varicosities. These results show that morphological parameters of transmitting nerve terminals can be adjusted to functionally compensate for genetic perturbations, thereby maintaining optimal synaptic transmission.
Key words: synaptic transmission; neuromuscular junction; electron microscopy; ultrastructure; cell adhesion molecule; Fasciclin II
This article has been cited by other articles:
J. S. Dason, J. Romero-Pozuelo, L. Marin, B. G. Iyengar, M. K. Klose, A. Ferrus, and H. L. Atwood
Frequenin/NCS-1 and the Ca2+-channel {alpha}1-subunit co-regulate synaptic transmission and nerve-terminal growth
J. Cell Sci., November 15, 2009; 122(22): 4109 - 4121.
[Abstract] [Full Text] [PDF]
P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser
Dendritic Excitability and Synaptic Plasticity
Physiol Rev, April 1, 2008; 88(2): 769 - 840.
[Abstract] [Full Text] [PDF]
F. Besse, S. Mertel, R. J. Kittel, C. Wichmann, T. M. Rasse, S. J. Sigrist, and A. Ephrussi
The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses
J. Cell Biol., June 21, 2007; 177(5): 843 - 855.
[Abstract] [Full Text] [PDF]
J. Ashley, M. Packard, B. Ataman, and V. Budnik
Fasciclin II Signals New Synapse Formation through Amyloid Precursor Protein and the Scaffolding Protein dX11/Mint
J. Neurosci., June 22, 2005; 25(25): 5943 - 5955.
[Abstract] [Full Text] [PDF]
B. Michels, S. Diegelmann, H. Tanimoto, I. Schwenkert, E. Buchner, and B. Gerber
A role for Synapsin in associative learning: The Drosophila larva as a study case
Learn. Mem., May 1, 2005; 12(3): 224 - 231.
[Abstract] [Full Text] [PDF]
D. Mathew, A. Popescu, and V. Budnik
Drosophila Amphiphysin Functions during Synaptic Fasciclin II Membrane Cycling
J. Neurosci., November 19, 2003; 23(33): 10710 - 10716.
[Abstract] [Full Text] [PDF]
S. J. Sigrist, D. F. Reiff, P. R. Thiel, J. R. Steinert, and C. M. Schuster
Experience-Dependent Strengthening of Drosophila Neuromuscular Junctions
J. Neurosci., July 23, 2003; 23(16): 6546 - 6556.
[Abstract] [Full Text] [PDF]
G. Adam, N. Perrimon, and S. Noselli
The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila
Development, June 1, 2003; 130(11): 2397 - 2406.
[Abstract] [Full Text] [PDF]
K. Beumer, H. J. G. Matthies, A. Bradshaw, and K. Broadie
Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development
Development, March 9, 2003; 129(14): 3381 - 3391.
[Abstract] [Full Text] [PDF]
J. R. Gray and J. C. Weeks
Steroid-Induced Dendritic Regression Reduces Anatomical Contacts between Neurons during Synaptic Weakening and the Developmental Loss of a Behavior
J. Neurosci., February 15, 2003; 23(4): 1406 - 1415.
[Abstract] [Full Text] [PDF]
S. Karunanithi, L. Marin, K. Wong, and H. L. Atwood
Quantal Size and Variation Determined by Vesicle Size in Normal and Mutant Drosophila Glutamatergic Synapses
J. Neurosci., December 1, 2002; 22(23): 10267 - 10276.
[Abstract] [Full Text] [PDF]
S. J. Sigrist, P. R. Thiel, D. F. Reiff, and C. M. Schuster
The Postsynaptic Glutamate Receptor Subunit DGluR-IIA Mediates Long-Term Plasticity in Drosophila
J. Neurosci., September 1, 2002; 22(17): 7362 - 7372.
[Abstract] [Full Text] [PDF]
J. P. Roche, M. C. Packard, S. Moeckel-Cole, and V. Budnik
Regulation of Synaptic Plasticity and Synaptic Vesicle Dynamics by the PDZ Protein Scribble
J. Neurosci., August 1, 2002; 22(15): 6471 - 6479.
[Abstract] [Full Text] [PDF]
M. L. Wainwright, H. Zhang, J. H. Byrne, and L. J. Cleary
Localized Neuronal Outgrowth Induced by Long-Term Sensitization Training in Aplysia
J. Neurosci., May 15, 2002; 22(10): 4132 - 4141.
[Abstract] [Full Text] [PDF]
H. Li, D. Harrison, G. Jones, D. Jones, and R. L. Cooper
Alterations in Development, Behavior, and Physiology in Drosophila Larva That Have Reduced Ecdysone Production
J Neurophysiol, January 1, 2001; 85(1): 98 - 104.
[Abstract] [Full Text] [PDF]
J. J. Renger, A. Ueda, H. L. Atwood, C. K. Govind, and C.-F. Wu
Role of cAMP Cascade in Synaptic Stability and Plasticity: Ultrastructural and Physiological Analyses of Individual Synaptic Boutons in Drosophila Memory Mutants
J. Neurosci., June 1, 2000; 20(11): 3980 - 3992.
[Abstract] [Full Text] [PDF]
M Sone, E Suzuki, M Hoshino, D Hou, H Kuromi, M Fukata, S Kuroda, K Kaibuchi, Y Nabeshima, and C Hama
Synaptic development is controlled in the periactive zones of Drosophila synapses
Development, January 10, 2000; 127(19): 4157 - 4168.
[Abstract] [PDF]
K. Wong, S. Karunanithi, and H. L. Atwood
Quantal Unit Populations at the Drosophila Larval Neuromuscular Junction
J Neurophysiol, September 1, 1999; 82(3): 1497 - 1511.
[Abstract] [Full Text] [PDF]
S. Karunanithi, J. W. Barclay, R. M. Robertson, I. R. Brown, and H. L. Atwood
Neuroprotection at Drosophila Synapses Conferred by Prior Heat Shock
J. Neurosci., June 1, 1999; 19(11): 4360 - 4369.
[Abstract] [Full Text] [PDF]
J. Roos and R. B. Kelly
Dap160, a Neural-specific Eps15 Homology and Multiple SH3 Domain-containing Protein That Interacts with Drosophila Dynamin
J. Biol. Chem., July 24, 1998; 273(30): 19108 - 19119.
[Abstract] [Full Text] [PDF]
G. Wu and H. T. Cline
Stabilization of Dendritic Arbor Structure in Vivo by CaMKII
Science, January 9, 1998; 279(5348): 222 - 226.
[Abstract] [Full Text]
M. Yoshihara, M. B. Rheuben, and Y. Kidokoro
Transition from Growth Cone to Functional Motor Nerve Terminal in Drosophila Embryos
J. Neurosci., November 1, 1997; 17(21): 8408 - 8426.
[Abstract] [Full Text] [PDF]
H. Zhu, F. Wu, and S. Schacher
Site-Specific and Sensory Neuron-Dependent Increases in Postsynaptic Glutamate Sensitivity Accompany Serotonin-Induced Long-Term Facilitation at Aplysia Sensorimotor Synapses
J. Neurosci., July 1, 1997; 17(13): 4976 - 4986.
[Abstract] [Full Text] [PDF]
P. Caroni, L. Aigner, and C. Schneider
Intrinsic Neuronal Determinants Locally Regulate Extrasynaptic and Synaptic Growth at the Adult Neuromuscular Junction
J. Cell Biol., February 10, 1997; 136(3): 679 - 692.
[Abstract] [Full Text] [PDF]
J. J. Renger, W.-D. Yao, M. B. Sokolowski, and C.-F. Wu
Neuronal Polymorphism among Natural Alleles of a cGMP-Dependent Kinase Gene, foraging, in Drosophila
J. Neurosci., October 1, 1999; 19(19): RC28 - RC28.
[Abstract] [Full Text] [PDF]
Y. Hatada, F. Wu, Z.-Y. Sun, S. Schacher, and D. J. Goldberg
Presynaptic Morphological Changes Associated with Long-Term Synaptic Facilitation Are Triggered by Actin Polymerization at Preexisting Varicositis
J. Neurosci., July 1, 2000; 20(13): RC82 - RC82.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|