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Volume 16, Number 12, Issue of June 15, 1996 pp. 3895-3899
Copyright ©1996 Society for Neuroscience

Nerve Growth Factor (NGF)-Mediated Protection of Neural Crest Cells from Antimitotic Agent-Induced Apoptosis: The Role of the Low-Affinity NGF Receptor

Received Feb. 20, 1996; revised March 28, 1996; accepted March 28, 1996.

Megan H. Cortazzo, Edmund S. Kassis, Kari A. Sproul, and Nina Felice Schor

Departments of Pediatrics, Neurology, and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213

Prevention by nerve growth factor (NGF) of apoptotic death in neural cells has been variously ascribed to binding of NGF to its low-affinity (p75) or high-affinity (trkA) receptor or to a cooperative interaction between the two. In a series of studies using, in turn, neuroblastoma cell lines that express only p75, mutant NGF species that bind selectively to either p75 or trkA, and a polyclonal antibody that binds to the NGF-binding domain of p75, we demonstrate that NGF binding to p75 is both necessary and sufficient for the abrogation of apoptosis in neuroblastoma cells treated with antimitotic agents.

Key words: neuroblastoma; NGF; NGF receptors; p75; trkA; apoptosis




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