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Volume 16, Number 12, Issue of June 15, 1996 pp. 4032-4040
Copyright ©1996 Society for Neuroscience

Functional Mapping of Human Learning: A Positron Emission Tomography Activation Study of Eyeblink Conditioning

Received Dec. 11, 1995; accepted March 27, 1996.

Teresa A. Blaxton1, Thomas A. Zeffiro2, John D. E. Gabrieli3, Susan Y. Bookheimer1, Maria C. Carrillo4, William H. Theodore1, and John F. Disterhoft4

1 Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, 2 Laboratory of Neurosciences, National Institute of Aging, Bethesda, Maryland 20892, 3 Department of Psychology, Stanford University, Stanford, California 94305, and 4 Department of Cell and Molecular Biology, Northwestern University, Chicago, Illinois 60611

Regional cerebral blood flow (rCBF) was measured using positron emission tomography during eyeblink conditioning in young adults. Subjects were scanned in three experimental conditions: delay conditioning, in which binaural tones preceded air puffs to the right eye by 400 msec; pseudoconditioning, in which presentations of tone and air puff stimuli were not correlated in time; and fixation rest, which served as a baseline control. Compared with fixation, pseudoconditioning produced rCBF increases in frontal and temporal cortex, basal ganglia, left hippocampal formation, and pons. Learning-specific activations were observed in conditioning as compared with pseudoconditioning in bilateral frontal cortex, left thalamus, right medial hippocampal formation, left lingual gyrus, pons, and bilateral cerebellum; decreases in rCBF were observed for bilateral temporal cortex, and in the right hemisphere in putamen, cerebellum, and the lateral aspect of hippocampal formation. Blood flow increased as the level of learning increased in the left hemisphere in caudate, hippocampal formation, fusiform gyrus, and cerebellum, and in right temporal cortex and pons. In contrast, activation in left frontal cortex decreased as learning increased. These functional imaging results implicate many of the same structures identified by previous lesion and recording studies of eyeblink conditioning in animals and humans and suggest that the same brain regions in animals and humans mediate multiple forms of associative learning that give meaning to a previously neutral stimulus.

Key words: learning; eyeblink conditioning; positron emission tomography (PET); cerebellum; hippocampus; frontal cortex; basal ganglia




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