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Volume 16, Number 13, Issue of July 1, 1996 pp. 4222-4230
Copyright ©1996 Society for Neuroscience

Mnemonic Responses of Single Units Recorded from Monkey Inferotemporal Cortex, Accessed via Transcommissural Versus Direct Pathways: A Dissociation between Unit Activity and Behavior

Received Dec. 26, 1995; revised April 1, 1996; accepted April 5, 1996.

Stanislaw Sobotka and James L. Ringo

Department of Physiology, University of Rochester Medical Center, Rochester, New York 14642-8642

Three macaques were trained on a task in which a sequence of single visual images was presented serially, and the monkeys signaled whether the image was a new or a repeated one. The optic chiasm and splenium of the corpus callosum were transected, leaving the anterior commissure as the only path for cortical interhemispheric transfer. Images were presented to only one eye at a time. Re-presentations of images to the same eye were recognized correctly in >95% of trials. A robust stimulus-specific adaptation (i.e., a reduced response to a repeated image) was seen in the population of single units recorded from inferotemporal cortex during these same trials. When an interhemispheric transfer was demanded of the animals (i.e., the re-presentation was made to the other eye), recognition performance was somewhat reduced, to 86% correct. Interestingly, in this situation the stimulus-specific adaptation disappeared completely. The disappearance occurred regardless of whether the transfer direction was from the hemisphere ipsilateral to the recording site to the hemisphere contralateral to the recording site, or vice versa. Thus, stimulus-specific adaptation in inferotemporal cortex units is not required for recognition.

Key words: visual memory; extrastriate cortex; inferotemporal cortex; macaque; memory; vision; interhemispheric relations

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