 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 16, Number 13, Issue of July 1, 1996 pp. 4261-4274
Copyright ©1996 Society for NeuroscienceThree-Dimensional Statistical Analysis of Sulcal Variability in the Human Brain
Received Dec. 18, 1995; revised March 19, 1996; accepted April 5, 1996.
Paul M. Thompson, Craig Schwartz, Robert T. Lin, Aelia A. Khan, and Arthur W. Toga Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, Los Angeles, California 90095
Morphometric variance of the human brain is qualitatively observable in surface features of the cortex. Statistical analysis of sulcal geometry will facilitate multisubject atlasing, neurosurgical studies, and multimodality brain mapping applications. This investigation describes the variability in location and geometry of five sulci surveyed in each hemisphere of six postmortem human brains placed within the Talairach stereotaxic grid. The sulci were modeled as complex internal surfaces in the brain. Heterogeneous profiles of three-dimensional (3D) variation were quantified locally within individual sulci.
Whole human heads, sectioned at 50 µm, were digitally photographed and high-resolution 3D data volumes were reconstructed. The parieto-occipital sulcus, the anterior and posterior rami of the calcarine sulcus, the cingulate and marginal sulci, and the supracallosal sulcus were delineated manually on sagittally resampled sections. Sulcal outlines were reparameterized for surface comparisons. Statistics of 3D variation for arbitrary points on each surface were calculated locally from the standardized individual data. Additional measures of surface area, extent in three dimensions, surface curvature, and fractal dimension were used to characterize variations in sulcal geometry.
Paralimbic sulci exhibited a greater degree of anterior- posterior variability than vertical variability. Occipital sulci displayed the reverse trend. Both trends were consistent with developmental growth patterns. Points on the occipital sulci displayed a profile of variability highly correlated with their 3D distance from the posterior commissure. Surface curvature was greater for the arched paralimbic sulci than for those bounding occipital gyri in each hemisphere. On the other hand, fractal dimension measures were remarkably similar for all sulci examined, and no significant hemispheric asymmetries were found for any of the selected spatial and geometric parameters. Implications of cortical morphometric variability for multisubject comparisons and brain mapping applications are discussed.
Key words: brain mapping; cortex; stereotaxic methods; sulcus; 3D image reconstruction; morphometry
This article has been cited by other articles:
S. Li, Y. Han, D. Wang, H. Yang, Y. Fan, Y. Lv, H. Tang, Q. Gong, Y. Zang, and Y. He
Mapping Surface Variability of the Central Sulcus in Musicians
Cereb Cortex, May 11, 2009; (2009) bhp074v1.
[Abstract] [Full Text] [PDF]
G. Gong, Y. He, L. Concha, C. Lebel, D. W. Gross, A. C. Evans, and C. Beaulieu
Mapping Anatomical Connectivity Patterns of Human Cerebral Cortex Using In Vivo Diffusion Tensor Imaging Tractography
Cereb Cortex, March 1, 2009; 19(3): 524 - 536.
[Abstract] [Full Text] [PDF]
J. J. Lin, N. Salamon, A. D. Lee, R. A. Dutton, J. A. Geaga, K. M. Hayashi, E. Luders, A. W. Toga, J. Engel Jr, and P. M. Thompson
Reduced Neocortical Thickness and Complexity Mapped in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Cereb Cortex, September 1, 2007; 17(9): 2007 - 2018.
[Abstract] [Full Text] [PDF]
D. S. Bassett, A. Meyer-Lindenberg, S. Achard, T. Duke, and E. Bullmore
From the Cover: Adaptive reconfiguration of fractal small-world human brain functional networks
PNAS, December 19, 2006; 103(51): 19518 - 19523.
[Abstract] [Full Text] [PDF]
J. A. Bobholz, S. M. Rao, L. Lobeck, C. Elsinger, A. Gleason, J. Kanz, S. Durgerian, and E. Maas
fMRI study of episodic memory in relapsing-remitting MS: correlation with T2 lesion volume.
Neurology, November 14, 2006; 67(9): 1640 - 1645.
[Abstract] [Full Text] [PDF]
E. Luders, K.L. Narr, E. Zaidel, P.M. Thompson, L. Jancke, and A.W. Toga
Parasagittal Asymmetries of the Corpus Callosum
Cereb Cortex, March 1, 2006; 16(3): 346 - 354.
[Abstract] [Full Text] [PDF]
J. T. Becker, S. W. Davis, K. M. Hayashi, C. C. Meltzer, A. W. Toga, O. L. Lopez, P. M. Thompson, and for the Imaging Methods and Analysis in Geriatrics
Three-dimensional Patterns of Hippocampal Atrophy in Mild Cognitive Impairment
Arch Neurol, January 1, 2006; 63(1): 97 - 101.
[Abstract] [Full Text] [PDF]
N. Bernasconi, D. Kinay, F. Andermann, S. Antel, and A. Bernasconi
Analysis of shape and positioning of the hippocampal formation: an MRI study in patients with partial epilepsy and healthy controls
Brain, October 1, 2005; 128(10): 2442 - 2452.
[Abstract] [Full Text] [PDF]
M. I. Miller, M. F. Beg, C. Ceritoglu, and C. Stark
Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping
PNAS, July 5, 2005; 102(27): 9685 - 9690.
[Abstract] [Full Text] [PDF]
R. Kotter and E. Wanke
Mapping brains without coordinates
Phil Trans R Soc B, April 29, 2005; 360(1456): 751 - 766.
[Abstract] [Full Text] [PDF]
P. M. Thompson, A. D. Lee, R. A. Dutton, J. A. Geaga, K. M. Hayashi, M. A. Eckert, U. Bellugi, A. M. Galaburda, J. R. Korenberg, D. L. Mills, et al.
Abnormal Cortical Complexity and Thickness Profiles Mapped in Williams Syndrome
J. Neurosci., April 20, 2005; 25(16): 4146 - 4158.
[Abstract] [Full Text] [PDF]
A. Fornito, M. Yucel, S. Wood, G. W. Stuart, J.-A. Buchanan, T. Proffitt, V. Anderson, D. Velakoulis, and C. Pantelis
Individual Differences in Anterior Cingulate/Paracingulate Morphology Are Related to Executive Functions in Healthy Males
Cereb Cortex, April 1, 2004; 14(4): 424 - 431.
[Abstract] [Full Text] [PDF]
B. Fischl, A. van der Kouwe, C. Destrieux, E. Halgren, F. Segonne, D. H. Salat, E. Busa, L. J. Seidman, J. Goldstein, D. Kennedy, et al.
Automatically Parcellating the Human Cerebral Cortex
Cereb Cortex, January 1, 2004; 14(1): 11 - 22.
[Abstract] [Full Text] [PDF]
E. Bullmore, J. Fadili, M. Breakspear, R. Salvador, J. Suckling, and M. Brammer
Wavelets and statistical analysis of functional magnetic resonance images of the human brain
Statistical Methods in Medical Research, October 1, 2003; 12(5): 375 - 399.
[Abstract] [PDF]
E. Luders, D.E. Rex, K.L. Narr, R.P. Woods, L. Jancke, P.M. Thompson, J.C. Mazziotta, and A.W. Toga
Relationships Between Sulcal Asymmetries and Corpus Callosum Size: Gender and Handedness Effects
Cereb Cortex, October 1, 2003; 13(10): 1084 - 1093.
[Abstract] [Full Text] [PDF]
V. A. Klyachko and C. F. Stevens
Connectivity optimization and the positioning of cortical areas
PNAS, June 24, 2003; 100(13): 7937 - 7941.
[Abstract] [Full Text] [PDF]
J. G. Csernansky, L. Wang, D. Jones, D. Rastogi-Cruz, J. A. Posener, G. Heydebrand, J. P. Miller, and M. I. Miller
Hippocampal Deformities in Schizophrenia Characterized by High Dimensional Brain Mapping
Am J Psychiatry, December 1, 2002; 159(12): 2000 - 2006.
[Abstract] [Full Text] [PDF]
A. W. Toga
Book Review: Imaging Databases and Neuroscience
Neuroscientist, October 1, 2002; 8(5): 423 - 436.
[Abstract] [PDF]
K. L. Narr, T. D. Cannon, R. P. Woods, P. M. Thompson, S. Kim, D. Asunction, T. G. M. van Erp, V.-P. Poutanen, M. Huttunen, J. Lonnqvist, et al.
Genetic Contributions to Altered Callosal Morphology in Schizophrenia
J. Neurosci., May 1, 2002; 22(9): 3720 - 3729.
[Abstract] [Full Text] [PDF]
J. Rademacher, U. Burgel, S. Geyer, T. Schormann, A. Schleicher, H.-J. Freund, and K. Zilles
Variability and asymmetry in the human precentral motor system: A cytoarchitectonic and myeloarchitectonic brain mapping study
Brain, November 1, 2001; 124(11): 2232 - 2258.
[Abstract] [Full Text] [PDF]
J. Mazziotta, A. Toga, A. Evans, P. Fox, J. Lancaster, K. Zilles, R. Woods, T. Paus, G. Simpson, B. Pike, et al.
A Four-Dimensional Probabilistic Atlas of the Human Brain
J. Am. Med. Inform. Assoc., September 1, 2001; 8(5): 401 - 430.
[Abstract] [Full Text] [PDF]
E.R. Sowell, S.N. Mattson, P.M. Thompson, T.L. Jernigan, E.P. Riley, and A.W. Toga
Mapping callosal morphology and cognitive correlates: Effects of heavy prenatal alcohol exposure
Neurology, July 24, 2001; 57(2): 235 - 244.
[Abstract] [Full Text] [PDF]
K. L. Narr, P. M. Thompson, T. Sharma, J. Moussai, C. Zoumalan, J. Rayman, and A. W. Toga
Three-Dimensional Mapping of Gyral Shape and Cortical Surface Asymmetries in Schizophrenia: Gender Effects
Am J Psychiatry, February 1, 2001; 158(2): 244 - 255.
[Abstract] [Full Text]
P. M. Thompson, M. S. Mega, R. P. Woods, C. I. Zoumalan, C. J. Lindshield, R. E. Blanton, J. Moussai, C. J. Holmes, J. L. Cummings, and A. W. Toga
Cortical Change in Alzheimer's Disease Detected with a Disease-specific Population-based Brain Atlas
Cereb Cortex, January 1, 2001; 11(1): 1 - 16.
[Abstract] [Full Text] [PDF]
V. Megalooikonomou, J. Ford, L. Shen, F. Makedon, and A. Saykin
Data mining in brain imaging
Statistical Methods in Medical Research, August 1, 2000; 9(4): 359 - 394.
[Abstract] [PDF]
G. Lohmann, D. Y. von Cramon, and H. Steinmetz
Sulcal Variability of Twins
Cereb Cortex, October 1, 1999; 9(7): 754 - 763.
[Abstract] [Full Text] [PDF]
A. Wolkin, H. Rusinek, G. Vaid, L. Arena, T. Lafargue, M. Sanfilipo, C. Loneragan, A. Lautin, and J. Rotrosen
Structural Magnetic Resonance Image Averaging in Schizophrenia
Am J Psychiatry, August 1, 1998; 155(8): 1064 - 1073.
[Abstract] [Full Text]
S. M. Rao, D. L. Harrington, K. Y. Haaland, J. A. Bobholz, R. W. Cox, and J. R. Binder
Distributed Neural Systems Underlying the Timing of Movements
J. Neurosci., July 15, 1997; 17(14): 5528 - 5535.
[Abstract] [Full Text] [PDF]
M. Miller, A. Banerjee, G. Christensen, S. Joshi, N. Khaneja, U. Grenander, and L. Matejic
Statistical methods in computational anatomy
Statistical Methods in Medical Research, June 1, 1997; 6(3): 267 - 299.
[Abstract] [PDF]
|
|
|
|
 |
|