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Volume 16, Number 13, Issue of July 1, 1996 pp. 4275-4282
Copyright ©1996 Society for Neuroscience

Cerebral Representation of One's Own Past: Neural Networks Involved in Autobiographical Memory

Received Dec. 19, 1995; revised April 16, 1996; accepted April 18, 1996.

Gereon R. Fink1, 2, Hans J. Markowitsch3, Mechthild Reinkemeier3, Thomas Bruckbauer1, Josef Kessler1, and Wolf-Dieter Heiss1, 2

1 Max-Planck-Institut für Neurologische Forschung, D-50931 Köln, Germany, 2 Universitätsklinik für Neurologie der Universität zu Köln, D-50924 Köln, Germany, and 3  Physiologische Psychologie, Universität Bielefeld, D-33501 Bielefeld, Germany

We studied the functional anatomy of affect-laden autobiographical memory in normal volunteers. Using H215O positron emission tomography (PET), we measured changes in relative regional cerebral blood flow (rCBF). Four rCBF measurements were obtained during three conditions: REST, i.e., subjects lay at rest (for control); IMPERSONAL, i.e., subjects listened to sentences containing episodic information taken from an autobiography of a person they did not know, but which had been presented to them before PET scanning (nonautobiographical episodic memory ecphory); and PERSONAL, i.e., subjects listened to sentences containing information taken from their own past (autobiographical episodic memory ecphory).

Comparing IMPERSONAL with REST (nonautobiographical episodic memory ecphory) resulted in relative rCBF increases symmetrically in both temporal lobes including the temporal poles and medial and superior temporal gyri. The same loci, however, with a stronger lateralization to the right hemisphere were activated in the comparison PERSONAL to REST (autobiographical episodic memory ecphory). In addition, the right temporomesial, right dorsal prefrontal, right posterior cingulate areas, and the left cerebellum were activated. A comparison of PERSONAL and IMPERSONAL (autobiographical vs nonautobiographical episodic memory ecphory) demonstrated a preponderantly right hemispheric activation including primarily right temporomesial and temporolateral cortex, right posterior cingulate areas, right insula, and right prefrontal areas. The right temporomesial activation included hippocampus, parahippocampus, and amygdala.

These results suggest that a right hemispheric network of temporal, together with posterior, cingulate, and prefrontal, areas is engaged in the ecphory of affect-laden autobiographical information.

Key words: PET; autobiographical memory; episodic memory; retrieval; cingulate; limbic system




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