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Volume 16, Number 13, Issue of July 1, 1996 pp. 4293-4299
Copyright ©1996 Society for NeuroscienceInduction of Hebbian and Non-Hebbian Mossy Fiber Long-Term Potentiation by Distinct Patterns of High-Frequency Stimulation
Received Feb. 28, 1996; revised April 1, 1996; accepted April 5, 1996.
Nathaniel N. Urban and German Barrionuevo Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
The synapse made by hippocampal mossy fibers onto pyramidal neurons of hippocampal area CA3 displays a form of long-term potentiation (LTP) that is independent of the activation of NMDA receptors. Considerable controversy exists as to whether the induction of mossy fiber LTP requires postsynaptic activation and, thus, whether mossy fiber LTP is Hebbian or non-Hebbian. Here we report the induction of both Hebbian and non-Hebbian forms of long-term potentiation at the mossy fiber-CA3 synapse in in vitro slice preparation. These two forms of potentiation can be induced selectively by different induction conditions. Sustained presynaptic activation is sufficient to induce the non-Hebbian form of mossy fiber LTP, whereas brief presynaptic activation coincident with postsynaptic depolarization is required to induce the Hebbian form. We suggest that non-Hebbian forms of plasticity may play an important role in dynamically regulating the thresholds for inducing Hebbian forms of plasticity.
Key words: hippocampus; CA3; LTP; mossy fiber; Hebbian; synaptic plasticity; granule cell; dentate gyrus; NMDA
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