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Volume 16, Number 14, Issue of July 15, 1996 pp. 4402-4410
Copyright ©1996 Society for Neuroscience

Neurotrophin-3 Antibodies Disrupt the Normal Development of the Chick Retina

Received Nov. 13, 1995; revised April 25, 1996; accepted May 1, 1996.

Paola Bovolenta¹, José-María Frade¹, Elisa Martí¹, María-Angeles Rodríguez-Peña², Yves-Alain Barde³, and Alfredo Rodríguez-Tébar¹

¹ Cajal Institute, Consejo Superior de Investigaciones Científicas, E-28002 Madrid, Spain, ² Instituto de Investigaciones Biomédicas, E-28008 Madrid, Spain, and ³ Max-Planck-Institute for Psychiatry, Department of Neurobiochemistry, 82152 Planegg-Martinsried, Germany

When chick embryos are treated with a monoclonal antibody specifically blocking the activity of neurotrophin-3 (NT-3), the development of the retina is profoundly affected. Fewer axons are found in the optic nerve, and the retina shows abnormalities in all layers. Early during retinogenesis, the proportion of dividing cells is higher in NT-3-deprived embryos compared with age-matched controls and that of differentiated neurons is smaller. The NT-3 receptor trkC is expressed early by a majority of retinal cells, and NT-3 is present in the retina at the earliest stage studied. Initially, it is located mainly in the pigmented epithelium, with a shift toward the neural retina as development proceeds. Thus, NT-3 seems to be an essential intrinsic signal acting early in development to promote the differentiation and survival of many retinal neurons.

Key words: retina; neuronal differentiation; retinal ganglion cells; cell number control; neurotrophin-3; chick embryo

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