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Next Article 
Volume 16, Number 15,
Issue of August 1, 1996
pp. 4537-4542
Copyright ©1996 Society for Neuroscience
Apical Dendritic Location of Slow Afterhyperpolarization Current
in Hippocampal Pyramidal Neurons: Implications for the Integration of
Long-Term Potentiation
Received Feb. 20, 1996; revised May 2, 1996; accepted May 7, 1996.
Pankaj Sah1 and
John M. Bekkers2
1 Neuroscience Group and the Discipline of Physiology,
University of Newcastle, New South Wales, Australia, and
2 Division of Neuroscience, John Curtin School of Medical
Research, Australian National University, Canberra, Australia
Trains of action potentials in hippocampal pyramidal neurons are
followed by a prolonged afterhyperpolarization (AHP) lasting several
seconds, which is attributable to the activation of a slow
calcium-activated potassium current (sIAHP). Here
we examine the location of sIAHP on CA1 pyramidal
neurons by comparing it with two GABAergic inhibitory postsynaptic
currents (IPSCs) with known somatic and dendritic locations. Whole-cell
patch-clamp recordings were made from CA1 pyramidal neurons in acute
hippocampal slices. Stepping the membrane potential at the peak of
sIAHP produced a relaxation (``switchoff'') of
the AHP current with a time constant of 7.4 ± 0.4 msec (mean ± SEM). The switchoff time constants for somatic and dendritic
GABAA IPSCs were 3.5 ± 0.5 msec and 8.8 ± 0.3 msec, respectively. This data, together with cable modeling, indicates
that active sIAHP channels are distributed over
the proximal dendrites within ~200 µm of the soma. Excitatory
postsynaptic potentials (EPSPs) evoked in stratum (s.) radiatum had
their amplitudes shunted more by the AHP than did EPSPs evoked in s.
oriens, suggesting that active AHP channels are restricted to the
apical dendritic tree. Blockade of the AHP during a tetanus, which in
control conditions elicited a decremental short-term potentiation
(STP), converted STP to long-term potentiation (LTP). Thus, activation
of the AHP increases the threshold for induction of LTP. These results
suggest that in addition to its established role in spike frequency
adaptation, the AHP works as an adjustable gain control, variably
hyperpolarizing and shunting synaptic potentials arising in the apical
dendrites.
Key words:
AHP;
cable analysis;
dendrite;
long-term potentiation;
potassium channel;
short-term potentiation
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