 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
Volume 16, Number 15, Issue of August 1, 1996 pp. 4776-4786
Copyright ©1996 Society for NeuroscienceUse-Dependent Exaggeration of Neuronal Injury after Unilateral Sensorimotor Cortex Lesions
Received Dec. 8, 1995; revised April 11, 1996; accepted April 16, 1996.
Dorothy A. Kozlowski, Debra C. James, and Timothy Schallert Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712
Unilateral injury to the forelimb representation area of the sensorimotor cortex (FL-SMC) in adult rats causes over-reliance on the unimpaired forelimb for postural-motor movements, as well as overgrowth of layer V pyramidal cell dendrites in the homotopic cortex of the noninjured hemisphere. The overgrowth appears to be use-dependent because it can be prevented by restricting movements of the unimpaired forelimb. Additionally, restricting the unimpaired forelimb in animals with FL-SMC damage results in significantly greater behavioral dysfunction when examined 2 d after cast removal (compared to that after impaired-limb immobilization, or no limb immobilization). In the present study, the long-term behavioral and anatomical effects of limb immobilization were examined. Animals with FL-SMC lesions were fitted with casts immediately after the lesion that immobilized the impaired forelimb, the unimpaired forelimb, or neither forelimb for 15 d. Immobilization of the nonimpaired forelimb resulted in chronic prevention of dendritic growth and severe and chronic behavioral deficits. In addition, immobilization of the nonimpaired forelimb resulted in a dramatic exaggeration of the neuronal injury, presumably attributable to forced overuse of the impaired limb. Immobilization of the impaired forelimb resulted in no detectable neural changes and in only slightly increased and longer-lasting behavioral asymmetries (compared to nonimmobilized, lesioned animals), presumably attributable to mild disuse of the impaired limb. Immobilization of a single forelimb in nonlesioned rats resulted in no significant behavioral or anatomical changes. Together, these results suggest that although behavioral experience can enhance neural growth after brain injury, the region surrounding the injury may be vulnerable to behavioral pressure during the early postlesion period.
Key words: recovery of function; stereology; use-dependent; sensorimotor cortex; forelimb immobilization; neuronal degeneration
This article has been cited by other articles:
M. A. Maldonado, R. P. Allred, E. L. Felthauser, and T. A. Jones
Motor Skill Training, but not Voluntary Exercise, Improves Skilled Reaching After Unilateral Ischemic Lesions of the Sensorimotor Cortex in Rats
Neurorehabil Neural Repair, June 1, 2008; 22(3): 250 - 261.
[Abstract] [PDF]
J. M. W. W. Myint, G. F. C. Yuen, T. K. K. Yu, C. P. L. Kng, A. M. Y. Wong, K. K. C. Chow, H. C. K. Li, and Chun Por Wong
A study of constraint-induced movement therapy in subacute stroke patients in Hong Kong
Clinical Rehabilitation, February 1, 2008; 22(2): 112 - 124.
[Abstract] [PDF]
J. A. Kleim and T. A. Jones
Principles of Experience-Dependent Neural Plasticity: Implications for Rehabilitation After Brain Damage
J Speech Lang Hear Res, February 1, 2008; 51(1): S225 - S239.
[Abstract] [Full Text] [PDF]
D. Ramanathan, J. M. Conner, and M. H. Tuszynski
A form of motor cortical plasticity that correlates with recovery of function after brain injury
PNAS, July 25, 2006; 103(30): 11370 - 11375.
[Abstract] [Full Text] [PDF]
S. Vaynman and F. Gomez-Pinilla
License to Run: Exercise Impacts Functional Plasticity in the Intact and Injured Central Nervous System by Using Neurotrophins
Neurorehabil Neural Repair, December 1, 2005; 19(4): 283 - 295.
[Abstract] [PDF]
B. A. Norrie, J. M. Nevett-Duchcherer, and M. A. Gorassini
Reduced Functional Recovery by Delaying Motor Training After Spinal Cord Injury
J Neurophysiol, July 1, 2005; 94(1): 255 - 264.
[Abstract] [Full Text] [PDF]
J. C. Grotta, E. A. Noser, T. Ro, C. Boake, H. Levin, J. Aronowski, and T. Schallert
Constraint-Induced Movement Therapy
Stroke, November 1, 2004; 35(11_suppl_1): 2699 - 2701.
[Abstract] [Full Text] [PDF]
K. J. Hutchinson, F. Gomez-Pinilla, M. J. Crowe, Z. Ying, and D. M. Basso
Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats
Brain, June 1, 2004; 127(6): 1403 - 1414.
[Abstract] [Full Text] [PDF]
W.-R. Schabitz, C. Berger, R. Kollmar, M. Seitz, E. Tanay, M. Kiessling, S. Schwab, and C. Sommer
Effect of Brain-Derived Neurotrophic Factor Treatment and Forced Arm Use on Functional Motor Recovery After Small Cortical Ischemia
Stroke, April 1, 2004; 35(4): 992 - 997.
[Abstract] [Full Text] [PDF]
J. Bernhardt, H. Dewey, A. Thrift, and G. Donnan
Inactive and Alone: Physical Activity Within the First 14 Days of Acute Stroke Unit Care
Stroke, April 1, 2004; 35(4): 1005 - 1009.
[Abstract] [Full Text] [PDF]
J. Biernaskie, G. Chernenko, and D. Corbett
Efficacy of Rehabilitative Experience Declines with Time after Focal Ischemic Brain Injury
J. Neurosci., February 4, 2004; 24(5): 1245 - 1254.
[Abstract] [Full Text] [PDF]
N. Byl, J. Roderick, O. Mohamed, M. Hanny, J. Kotler, A. Smith, M. Tang, and G. Abrams
Effectiveness of Sensory and Motor Rehabilitation of the Upper Limb Following the Principles of Neuroplasticity: Patients Stable Poststroke
Neurorehabil Neural Repair, September 1, 2003; 17(3): 176 - 191.
[Abstract] [PDF]
S. B. DeBow, M. L.A. Davies, H. L. Clarke, and F. Colbourne
Constraint-Induced Movement Therapy and Rehabilitation Exercises Lessen Motor Deficits and Volume of Brain Injury After Striatal Hemorrhagic Stroke in Rats
Stroke, April 1, 2003; 34(4): 1021 - 1026.
[Abstract] [Full Text] [PDF]
J. L. Tillerson, A. D. Cohen, W. M. Caudle, M. J. Zigmond, T. Schallert, and G. W. Miller
Forced Nonuse in Unilateral Parkinsonian Rats Exacerbates Injury
J. Neurosci., August 1, 2002; 22(15): 6790 - 6799.
[Abstract] [Full Text] [PDF]
A Cifelli and P M Matthews
Cerebral plasticity in multiple sclerosis: insights from fMRI
Multiple Sclerosis, June 1, 2002; 8(3): 193 - 199.
[Abstract] [PDF]
J. Biernaskie and D. Corbett
Enriched Rehabilitative Training Promotes Improved Forelimb Motor Function and Enhanced Dendritic Growth after Focal Ischemic Injury
J. Neurosci., July 15, 2001; 21(14): 5272 - 5280.
[Abstract] [Full Text] [PDF]
J. L. Tillerson, A. D. Cohen, J. Philhower, G. W. Miller, M. J. Zigmond, and T. Schallert
Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine
J. Neurosci., June 15, 2001; 21(12): 4427 - 4435.
[Abstract] [Full Text] [PDF]
R. Pineiro, S. Pendlebury, H. Johansen-Berg, and P. M. Matthews
Functional MRI Detects Posterior Shifts in Primary Sensorimotor Cortex Activation After Stroke : Evidence of Local Adaptive Reorganization?
Stroke, May 1, 2001; 32(5): 1134 - 1139.
[Abstract] [Full Text] [PDF]
A. W. Dromerick, D. F. Edwards, and M. Hahn
Does the Application of Constraint-Induced Movement Therapy During Acute Rehabilitation Reduce Arm Impairment After Ischemic Stroke?
Stroke, December 1, 2000; 31(12): 2984 - 2988.
[Abstract] [Full Text] [PDF]
S. T. Bland, T. Schallert, R. Strong, J. Aronowski, J. C. Grotta, and D. M. Feeney
Early Exclusive Use of the Affected Forelimb After Moderate Transient Focal Ischemia in Rats : Functional and Anatomic Outcome Editorial Comment: Functional and Anatomic Outcome
Stroke, May 1, 2000; 31(5): 1144 - 1152.
[Abstract] [Full Text] [PDF]
B. B. Johansson
Brain Plasticity and Stroke Rehabilitation : The Willis Lecture
Stroke, January 1, 2000; 31(1): 223 - 230.
[Abstract] [Full Text] [PDF]
T. A. Jones, C. J. Chu, L. A. Grande, and A. D. Gregory
Motor Skills Training Enhances Lesion-Induced Structural Plasticity in the Motor Cortex of Adult Rats
J. Neurosci., November 15, 1999; 19(22): 10153 - 10163.
[Abstract] [Full Text] [PDF]
G. Nelles, G. Spiekermann, M. Jueptner, G. Leonhardt, S. Muller, H. Gerhard, and H. C. Diener
Reorganization of Sensory and Motor Systems in Hemiplegic Stroke Patients : A Positron Emission Tomography Study
Stroke, August 1, 1999; 30(8): 1510 - 1516.
[Abstract] [Full Text] [PDF]
Y. Liu, D. Kim, B. T. Himes, S. Y. Chow, T. Schallert, M. Murray, A. Tessler, and I. Fischer
Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function
J. Neurosci., June 1, 1999; 19(11): 4370 - 4387.
[Abstract] [Full Text] [PDF]
E. Brustein and S. Rossignol
Recovery of Locomotion After Ventral and Ventrolateral Spinal Lesions in the Cat. I. Deficits and Adaptive Mechanisms
J Neurophysiol, September 1, 1998; 80(3): 1245 - 1267.
[Abstract] [Full Text] [PDF]
F. Colbourne, R. N. Auer, G. R. Sutherland, and W. D. Dietrich
Behavioral Testing Does Not Exacerbate Ischemic CA1 Damage in Gerbils • Editorial Comment
Stroke, September 1, 1998; 29(9): 1967 - 1971.
[Abstract] [Full Text] [PDF]
Y. Li, N. Jiang, C. Powers, M. Chopp, and B. B. Johansson
Neuronal Damage and Plasticity Identified by Microtubule-Associated Protein 2, Growth-Associated Protein 43, and Cyclin D1 Immunoreactivity After Focal Cerebral Ischemia in Rats • Editorial Comment
Stroke, September 1, 1998; 29(9): 1972 - 1981.
[Abstract] [Full Text] [PDF]
G. Nelles, S. C. Cramer, J. D. Schaechter, J. D. Kaplan, and S. P. Finklestein
Quantitative Assessment of Mirror Movements After Stroke
Stroke, June 1, 1998; 29(6): 1182 - 1187.
[Abstract] [Full Text] [PDF]
S. C. Cramer, G. Nelles, R. R. Benson, J. D. Kaplan, R. A. Parker, K. K. Kwong, D. N. Kennedy, S. P. Finklestein, and B. R. Rosen
A Functional MRI Study of Subjects Recovered From Hemiparetic Stroke
Stroke, December 1, 1997; 28(12): 2518 - 2527.
[Abstract] [Full Text]
R. Shadmehr and H. H. Holcomb
Neural Correlates of Motor Memory Consolidation
Science, August 8, 1997; 277(5327): 821 - 825.
[Abstract] [Full Text]
D. Miya, S. Giszter, F. Mori, V. Adipudi, A. Tessler, and M. Murray
Fetal Transplants Alter the Development of Function after Spinal Cord Transection in Newborn Rats
J. Neurosci., June 15, 1997; 17(12): 4856 - 4872.
[Abstract] [Full Text] [PDF]
B. A. Norrie, J. M. Nevett-Duchcherer, and M. A. Gorassini
Reduced Functional Recovery by Delaying Motor Training After Spinal Cord Injury
J Neurophysiol, July 1, 2005; 94(1): 255 - 264.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|