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Volume 16, Number 15,
Issue of August 1, 1996
pp. 4799-4809
Copyright ©1996 Society for Neuroscience
Protein Kinase and G-Protein Regulation of Ca2+
Currents in Hermissenda Photoreceptors by 5-HT and GABA
Received Feb. 21, 1996; revised April 30, 1996; accepted May 3, 1996.
Ebenezer N. Yamoah and
Terry Crow
Department of Neurobiology and Anatomy, University of Texas Medical
School, Houston, Texas 77225
The effects of serotonin (5-HT) and GABA on two
Ca2+ currents, a transient low-voltage-activated
current (tLVA) and a sustained high-voltage-activated current (sHVA)
were examined in isolated photoreceptors of Hermissenda. The
sHVA current was blocked by 5-HT and reduced by activation of protein
kinase C (PKC) with phorbol 12-myristate 13-acetate. The effects of
5-HT were transiently reversed by staurosporine and partially blocked
by the PKC inhibitor peptide [PKC(19-36)]. GABA enhanced both the
tLVA and sHVA currents at low concentrations (5 nM to 5 µM) and reduced
the sHVA current at high concentrations (>10
µM). The GABA-mediated enhancement of the
Ca2+ current at low concentrations was sensitive
to block by picrotoxin. The protein kinase A (PKA) inhibitor peptide
[PKI(6-22)amide] blocked enhancement of both
Ca2+ currents produced by cAMP analogs and GABA,
suggesting that the effects at low concentrations may be PKA mediated.
Caged GTP- -S released by flash photolysis reduced the sHVA current,
and pretreatment of the photoreceptors with pertussis toxin blocked the
effects of higher concentrations of GABA, indicating that at higher
concentrations, the effects may be G-protein mediated.
Key words:
calcium current;
-aminobutyric acid;
neuromodulation;
cellular plasticity;
Hermissenda;
serotonin
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