QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (20) Citing Articles via Google Scholar Google Scholar Articles by Stopfer, M. Articles by Carew, T. J. Search for Related Content PubMed PubMed Citation Articles by Stopfer, M. Articles by Carew, T. J.

 Previous Article  |  Next Article 

Volume 16, Number 16, Issue of August 15, 1996 pp. 4923-4932
Copyright ©1996 Society for Neuroscience

Site Specificity of Short-Term and Long-Term Habituation in the Tail-Elicited Siphon Withdrawal Reflex of Aplysia

Received Feb. 5, 1996; revised May 22, 1996; accepted May 24, 1996.

Mark Stopfer¹, Xinghai Chen¹, Yu-Tzu Tai¹, Gloria S. Huang¹, and Thomas J. Carew^{1, 2}

Departments of ¹ Psychology and ² Biology, Yale University, New Haven, Connecticut 06520-8205

The study of habituation in animals with relatively simple nervous systems has contributed significantly to the understanding of mechanisms underlying learning and memory. Using the tail-elicited siphon withdrawal reflex of Aplysia, which is mediated in part by bilaterally symmetrical clusters of tail sensory neurons, we found that both short-term and long-term habituation can be restricted laterally, such that habituation produced by stimulation of one side of the tail does not generalize to the other side. Further experiments in this preparation revealed that long-term, laterally restricted habituation is sensitive to the temporal pattern with which stimuli are presented. We also determined that both short-term and long-term habituation can take place in a reduced behavioral preparation, and that short-term habituation can be restricted within relatively small stimulation sites located on the same side of the tail. These results provide insights into the cellular organization of habituation, and they provide a useful preparation for a cellular analysis of this basic form of learning.

Key words: Aplysia; habituation; specificity; long-term; learning; tail; siphon

This article has been cited by other articles:

				D. A. Wilson and C. Linster Neurobiology of a Simple Memory J Neurophysiol, July 1, 2008; 100(1): 2 - 7. [Abstract] [Full Text] [PDF]

				E. G. Antzoulatos and J. H. Byrne Long-Term Sensitization Training Produces Spike Narrowing in Aplysia Sensory Neurons J. Neurosci., January 17, 2007; 27(3): 676 - 683. [Abstract] [Full Text] [PDF]

				W. N. Frost, C. L. Brandon, and C. Van Zyl Long-Term Habituation in the Marine Mollusc Tritonia diomedea Biol. Bull., June 1, 2006; 210(3): 230 - 237. [Abstract] [Full Text] [PDF]

				H.-Y. Cheng and D. F. Clayton Activation and Habituation of Extracellular Signal-Regulated Kinase Phosphorylation in Zebra Finch Auditory Forebrain during Song Presentation J. Neurosci., August 25, 2004; 24(34): 7503 - 7513. [Abstract] [Full Text] [PDF]

				A. S. Bristol, M. A. Sutton, and T. J. Carew Neural Circuit of Tail-Elicited Siphon Withdrawal in Aplysia. I. Differential Lateralization of Sensitization and Dishabituation J Neurophysiol, February 1, 2004; 91(2): 666 - 677. [Abstract] [Full Text] [PDF]

				A. S. Bristol, S. Marinesco, and T. J. Carew Neural Circuit of Tail-Elicited Siphon Withdrawal in Aplysia. II. Role of Gated Inhibition in Differential Lateralization of Sensitization and Dishabituation J Neurophysiol, February 1, 2004; 91(2): 678 - 692. [Abstract] [Full Text] [PDF]

				Y. Ezzeddine and D. L. Glanzman Prolonged Habituation of the Gill-Withdrawal Reflex in Aplysia Depends on Protein Synthesis, Protein Phosphatase Activity, and Postsynaptic Glutamate Receptors J. Neurosci., October 22, 2003; 23(29): 9585 - 9594. [Abstract] [Full Text] [PDF]

				R. Nargeot Voltage-Dependent Switching of Sensorimotor Integration by a Lobster Central Pattern Generator J. Neurosci., June 15, 2003; 23(12): 4803 - 4808. [Abstract] [Full Text] [PDF]

				U. Muller and H. Hildebrandt Nitric Oxide/cGMP-Mediated Protein Kinase A Activation in the Antennal Lobes Plays an Important Role in Appetitive Reflex Habituation in the Honeybee J. Neurosci., October 1, 2002; 22(19): 8739 - 8747. [Abstract] [Full Text] [PDF]

				K. Yasunari, M. Kohno, H. Kano, M. Minami, and J. Yoshikawa Dopamine as a Novel Antioxidative Agent for Rat Vascular Smooth Muscle Cells Through Dopamine D1-Like Receptors Circulation, May 16, 2000; 101(19): 2302 - 2308. [Abstract] [Full Text] [PDF]

				M. Levy and A. J. Susswein Separate Effects of a Classical Conditioning Procedure on Respiratory Pumping, Swimming, and Inking in Aplysia fasciata Learn. Mem., January 1, 1999; 6(1): 21 - 36. [Abstract] [Full Text]

				B. D. Burrell and C. L. Sahley Generalization of Habituation and Intrinsic Sensitization in the Leech Learn. Mem., November 1, 1998; 5(6): 405 - 419. [Abstract] [Full Text]

				M. Stopfer and T. J. Carew Heterosynaptic Facilitation of Tail Sensory Neuron Synaptic Transmission during Habituation in Tail-Induced Tail and Siphon Withdrawal Reflexes of Aplysia J. Neurosci., August 15, 1996; 16(16): 4933 - 4948. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help