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Volume 16, Number 17, Issue of September 1, 1996 pp. 5334-5343
Copyright ©1996 Society for NeuroscienceLong-Term Potentiation in Distinct Subtypes of Hippocampal Nonpyramidal Neurons
Received April 30, 1996; revised June 4, 1996; accepted June 6, 1996.
Gianmaria Maccaferri and Chris J. McBain National Institute of Child Health and Human Development, Laboratory of Cellular and Molecular Neurophysiology, Bethesda, Maryland 20892-4495
We have investigated NMDA receptor-dependent long-term potentiation (LTP) in distinct subtypes of nonpyramidal neurons of the CA1 hippocampus using induction protocols that permitted the differentiation between a direct form of LTP and plasticity resulting simply from the ``passive propagation'' of LTP occurring on CA1 pyramidal neurons. Two types of stratum (st.) oriens/alveus interneurons received passive propagation of synaptic potentiation via the recurrent collaterals of CA1 pyramidal cells, but neither subtype possessed direct plasticity. In st. radiatum, two distinct classes of cells were observed: st. radiatum interneurons that showed neither direct nor propagated forms of synaptic plasticity, and ``giant cells'' for which EPSPs were robustly potentiated after a pairing protocol. This potentiation is similar to the LTP described in pyramidal cells, and its induction requires NMDA receptor activation. Thus, a large heterogeneity of synaptic plasticity exists in morphologically distinct neurons and suggests that complex changes in the CA1 network properties will occur after the induction of LTP.
Key words: hippocampus; interneurons; LTP; plasticity; GABAergic; CA1
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