 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
Volume 16, Number 17, Issue of September 1, 1996 pp. 5361-5371
Copyright ©1996 Society for NeuroscienceMice Lacking Brain-Derived Neurotrophic Factor Exhibit Visceral Sensory Neuron Losses Distinct from Mice Lacking NT4 and Display a Severe Developmental Deficit in Control of Breathing
Received April 25, 1996; revised June 6, 1996; accepted June 12, 1996.
Jeffery T. Erickson1, Joanne C. Conover2, Veronique Borday3, Jean Champagnat3, Mariano Barbacid4, George Yancopoulos2, and David M. Katz1 1 Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, 2 Regeneron Pharmaceuticals, Tarrytown, New York 10591, 3 Institut Alfred Fessard, 91198 Gif-Sur-Yvette Cedex, France, and 4 Bristol-Myers Squibb, Princeton, New Jersey 08543
The neurotrophins brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT4) act via the TrkB receptor and support survival of primary somatic and visceral sensory neurons. The major visceral sensory population, the nodose-petrosal ganglion complex (NPG), requires BDNF and NT4 for survival of a full complement of neurons, providing a unique opportunity to compare gene dosage effects between the two TrkB ligands and to explore the possibility that one ligand can compensate for loss of the other. Analysis of newborn transgenic mice lacking BDNF or NT4, or BDNF and NT4, revealed that survival of many NPG afferents is proportional to the number of functional BDNF alleles, whereas only one functional NT4 allele is required to support survival of all NT4-dependent neurons. In addition, subpopulation analysis revealed that BDNF and NT4 can compensate for the loss of the other to support a subset of dopaminergic ganglion cells. Together, these data demonstrate that the pattern of neuronal dependencies on BDNF and NT4 in vivo is far more heterogeneous than predicted from previous studies in culture. Moreover, BDNF knockout animals lack a subset of afferents involved in ventilatory control and exhibit severe respiratory abnormalities characterized by depressed and irregular breathing and reduced chemosensory drive. BDNF is therefore required for expression of normal respiratory behavior in newborn animals.
Key words: chemoreceptor; neurotrophin; nodose; petrosal; respiration; Sudden Infant Death Syndrome
This article has been cited by other articles:
C. Gaultier and J Gallego
Neural control of breathing: insights from genetic mouse models
J Appl Physiol, May 1, 2008; 104(5): 1522 - 1530.
[Abstract] [Full Text] [PDF]
V. Dubreuil, N. Ramanantsoa, D. Trochet, V. Vaubourg, J. Amiel, J. Gallego, J.-F. Brunet, and C. Goridis
A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons
PNAS, January 22, 2008; 105(3): 1067 - 1072.
[Abstract] [Full Text] [PDF]
M. Kron, M. Morschel, J. Reuter, W. Zhang, and M. Dutschmann
Developmental changes in brain-derived neurotrophic factor-mediated modulations of synaptic activities in the pontine Kolliker Fuse nucleus of the rat
J. Physiol., August 15, 2007; 583(1): 315 - 327.
[Abstract] [Full Text] [PDF]
D. Ize-Ludlow, J. A. Gray, M. A. Sperling, E. M. Berry-Kravis, J. M. Milunsky, I. S. Farooqi, C. M. Rand, and D. E. Weese-Mayer
Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Presenting in Childhood
Pediatrics, July 1, 2007; 120(1): e179 - e188.
[Abstract] [Full Text] [PDF]
H. Wang, S.-a. Chan, M. Ogier, D. Hellard, Q. Wang, C. Smith, and D. M. Katz
Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in mecp2 null mice.
J. Neurosci., October 18, 2006; 26(42): 10911 - 10915.
[Abstract] [Full Text] [PDF]
E. A. Fox and M. S. Byerly
A mechanism underlying mature-onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R994 - R1004.
[Abstract] [Full Text] [PDF]
E. Nsegbe, A. Wallen-Mackenzie, S. Dauger, J.-C. Roux, Y. Shvarev, H. Lagercrantz, T. Perlmann, and E. Herlenius
Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice
J. Physiol., April 1, 2004; 556(1): 43 - 59.
[Abstract] [Full Text] [PDF]
M. Thoby-Brisson, B. Cauli, J. Champagnat, G. Fortin, and D. M. Katz
Expression of Functional Tyrosine Kinase B Receptors by Rhythmically Active Respiratory Neurons in the Pre-Botzinger Complex of Neonatal Mice
J. Neurosci., August 20, 2003; 23(20): 7685 - 7689.
[Abstract] [Full Text] [PDF]
J. L. Carroll
Plasticity in Respiratory Motor Control: Invited Review: Developmental plasticity in respiratory control
J Appl Physiol, January 1, 2003; 94(1): 375 - 389.
[Abstract] [Full Text] [PDF]
A. Postigo, A. M. Calella, B. Fritzsch, M. Knipper, D. Katz, A. Eilers, T. Schimmang, G. R. Lewin, R. Klein, and L. Minichiello
Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons
Genes & Dev., March 1, 2002; 16(5): 633 - 645.
[Abstract] [Full Text] [PDF]
E. A. Fox, R. J. Phillips, E. A. Baronowsky, M. S. Byerly, S. Jones, and T. L. Powley
Neurotrophin-4 Deficient Mice Have a Loss of Vagal Intraganglionic Mechanoreceptors from the Small Intestine and a Disruption of Short-Term Satiety
J. Neurosci., November 1, 2001; 21(21): 8602 - 8615.
[Abstract] [Full Text] [PDF]
Y. Qian, B. Fritzsch, S. Shirasawa, C.-L. Chen, Y. Choi, and Q. Ma
Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3
Genes & Dev., October 1, 2001; 15(19): 2533 - 2545.
[Abstract] [Full Text] [PDF]
C. E. HUNT
Sudden Infant Death Syndrome and Other Causes of Infant Mortality . Diagnosis, Mechanisms, and Risk for Recurrence in Siblings
Am. J. Respir. Crit. Care Med., August 1, 2001; 164(3): 346 - 357.
[Full Text] [PDF]
H. Burnet, M. Bevengut, F. Chakri, C. Bou-Flores, P. Coulon, S. Gaytan, R. Pasaro, and G. Hilaire
Altered Respiratory Activity and Respiratory Regulations in Adult Monoamine Oxidase A-Deficient Mice
J. Neurosci., July 15, 2001; 21(14): 5212 - 5221.
[Abstract] [Full Text] [PDF]
A. Roosen, A. Schober, J. Strelau, M. Bottner, J. Faulhaber, G. Bendner, S. L. McIlwrath, H. Seller, H. Ehmke, G. R. Lewin, et al.
Lack of Neurotrophin-4 Causes Selective Structural and Chemical Deficits in Sympathetic Ganglia and Their Preganglionic Innervation
J. Neurosci., May 1, 2001; 21(9): 3073 - 3084.
[Abstract] [Full Text] [PDF]
J. T. Erickson, T. A. Brosenitsch, and D. M. Katz
Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor Are Required Simultaneously for Survival of Dopaminergic Primary Sensory Neurons In Vivo
J. Neurosci., January 15, 2001; 21(2): 581 - 589.
[Abstract] [Full Text] [PDF]
A. Balkowiec and D. M. Katz
Activity-Dependent Release of Endogenous Brain-Derived Neurotrophic Factor from Primary Sensory Neurons Detected by ELISA In Situ
J. Neurosci., October 1, 2000; 20(19): 7417 - 7423.
[Abstract] [Full Text] [PDF]
D. F. Donnelly
Developmental aspects of oxygen sensing by the carotid body
J Appl Physiol, June 1, 2000; 88(6): 2296 - 2301.
[Abstract] [Full Text] [PDF]
D. M. Robinson, H. Kwok, B. M. Adams, K. C. Peebles, and G. D. Funk
Development of the ventilatory response to hypoxia in Swiss CD-1 mice
J Appl Physiol, May 1, 2000; 88(5): 1907 - 1914.
[Abstract] [Full Text] [PDF]
C Baudet, A Mikaels, H Westphal, J Johansen, T. Johansen, and P Ernfors
Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins
Development, January 10, 2000; 127(20): 4335 - 4344.
[Abstract] [PDF]
M. B. Lips and B. U. Keller
Activity-Related Calcium Dynamics in Motoneurons of the Nucleus Hypoglossus From Mouse
J Neurophysiol, December 1, 1999; 82(6): 2936 - 2946.
[Abstract] [Full Text] [PDF]
A. Braun, M. Lommatzsch, A. Mannsfeldt, U. Neuhaus-Steinmetz, A. Fischer, N. Schnoy, G. R. Lewin, and H. Renz
Cellular Sources of Enhanced Brain-Derived Neurotrophic Factor Production in a Mouse Model of Allergic Inflammation
Am. J. Respir. Cell Mol. Biol., October 1, 1999; 21(4): 537 - 546.
[Abstract] [Full Text]
M. Lommatzsch, A. Braun, A. Mannsfeldt, V. A. Botchkarev, N. V. Botchkareva, R. Paus, A. Fischer, G. R. Lewin, and H. Renz
Abundant Production of Brain-Derived Neurotrophic Factor by Adult Visceral Epithelia : Implications for Paracrine and Target-Derived NeurotrophicFunctions
Am. J. Pathol., October 1, 1999; 155(4): 1183 - 1193.
[Abstract] [Full Text] [PDF]
A. M. LeMaster, R. F. Krimm, B. M. Davis, T. Noel, M. E. Forbes, J. E. Johnson, and K. M. Albers
Overexpression of Brain-Derived Neurotrophic Factor Enhances Sensory Innervation and Selectively Increases Neuron Number
J. Neurosci., July 15, 1999; 19(14): 5919 - 5931.
[Abstract] [Full Text] [PDF]
K. L. Boeshore, C. N. Luckey, R. E. Zigmond, and T. H. Large
TrkB Isoforms with Distinct Neurotrophin Specificities Are Expressed in Predominantly Nonoverlapping Populations of Avian Dorsal Root Ganglion Neurons
J. Neurosci., June 15, 1999; 19(12): 4739 - 4747.
[Abstract] [Full Text] [PDF]
R. Brady, S. I. A. Zaidi, C. Mayer, and D. M. Katz
BDNF Is a Target-Derived Survival Factor for Arterial Baroreceptor and Chemoafferent Primary Sensory Neurons
J. Neurosci., March 15, 1999; 19(6): 2131 - 2142.
[Abstract] [Full Text] [PDF]
M. E. Palko, V. Coppola, and L. Tessarollo
Evidence for a Role of Truncated trkC Receptor Isoforms in Mouse Development
J. Neurosci., January 15, 1999; 19(2): 775 - 782.
[Abstract] [Full Text] [PDF]
C. L. Stucky, T. DeChiara, R. M. Lindsay, G. D. Yancopoulos, and M. Koltzenburg
Neurotrophin 4 Is Required for the Survival of a Subclass of Hair Follicle Receptors
J. Neurosci., September 1, 1998; 18(17): 7040 - 7046.
[Abstract] [Full Text] [PDF]
K. Kolandaivelu and C.-S. Poon
A miniature mechanical ventilator for newborn mice
J Appl Physiol, February 1, 1998; 84(2): 733 - 739.
[Abstract] [Full Text] [PDF]
W. M. ElShamy and P. Ernfors
Brain-Derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4 Complement and Cooperate with Each Other Sequentially during Visceral Neuron Development
J. Neurosci., November 15, 1997; 17(22): 8667 - 8675.
[Abstract] [Full Text] [PDF]
C. Nosrat, J Blomlof, W. ElShamy, P Ernfors, and L Olson
Lingual deficits in BDNF and NT3 mutant mice leading to gustatory and somatosensory disturbances, respectively
Development, January 4, 1997; 124(7): 1333 - 1342.
[Abstract] [PDF]
R. A. Johnson, A. J. Okragly, M. Haak-Frendscho, and G. S. Mitchell
Cervical Dorsal Rhizotomy Increases Brain-Derived Neurotrophic Factor and Neurotrophin-3 Expression in the Ventral Spinal Cord
J. Neurosci., May 15, 2000; 20(10): RC77 - RC77.
[Abstract] [Full Text] [PDF]
S. DAUGER, F. GUIMIOT, S. RENOLLEAU, B. LEVACHER, B. BODA, C. MAS, V. NEPOTE, M. SIMONNEAU, C. GAULTIER, and J. GALLEGO
MASH-1/RET pathway involvement in development of brain stem control of respiratory frequency in newborn mice
Physiol Genomics, December 21, 2001; 7(2): 149 - 157.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|