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Volume 16, Number 18, Issue of September 15, 1996 pp. 5762-5776
Copyright ©1996 Society for NeuroscienceInterkinetic and Migratory Behavior of a Cohort of Neocortical Neurons Arising in the Early Embryonic Murine Cerebral Wall
Received April 16, 1996; revised June 28, 1996; accepted July 2, 1996.
Takao Takahashi1, Richard S. Nowakowski2, and Verne S. Caviness Jr.1 1 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, 2 Department of Pediatrics, Keio University School of Medicine, Tokyo 160, Japan, and 3 Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854
Neocortical neuronogenesis occurs in the pseudostratified ventricular epithelium (PVE) where nuclei of proliferative cells undergo interkinetic nuclear movement. A fraction of daughter cells exits the cell cycle as neurons (the quiescent, or Q, fraction), whereas a complementary fraction remains in the cell cycle (the proliferative, or P, fraction). By means of sequential thymidine and bromodeoxyuridine injections in mouse on embryonic day 14, we have monitored the proliferative and postmitotic migratory behaviors of 1 and 2 hr cohorts of PVE cells defined by the injection protocols. Soon after mitosis, the Q fraction partitions into a rapidly exiting (up to 50 µm/hr) subpopulation (Qr) and a more slowly exiting (6 µm/hr) subpopulation (Qs). Qr and Qs are separated as two distributions on exit from the ventricular zone with an interpeak distance of ~40 µm. Cells in Qr and Qs migrate through the intermediate zone with no significant change in the interpeak distance, suggesting that they migrate at approximately the same velocities. The rate of migration increases with ascent through the intermediate zone (average 2-6.4 µm/hr) slowing only transiently on entry into the developing cortex. Within the cortex, Qr and Qs merge to form a single distribution most concentrated over layer V.
Key words: neocortical neuronogenesis; cell cycle; proliferation; neuronal migration; mouse; ventricular zone
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