Modulatory Actions of Dopamine on NMDA Receptor-Mediated Responses Are Reduced in D1A-Deficient Mutant Mice

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

HOME | SEARCH | ARCHIVE | SUBSCRIBE | CONTACT | HELP

This Article

Full Text

Full Text (PDF)

Submit an eLetter

Alert me when this article is cited

Alert me when eLetters are posted

Alert me if a correction is posted

Citation Map

Services

Email this article to a friend

Similar articles in this journal

Similar articles in ISI Web of Science

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via ISI Web of Science (97)

Citing Articles via Google Scholar

Google Scholar

Articles by Levine, M. S.

Articles by Westphal, H.

Search for Related Content

PubMed

PubMed Citation

Articles by Levine, M. S.

Articles by Westphal, H.

Previous Article | Next Article

Volume 16, Number 18, Issue of September 15, 1996 pp. 5870-5882
Copyright ©1996 Society for Neuroscience

Modulatory Actions of Dopamine on NMDA Receptor-Mediated Responses Are Reduced in D_1A-Deficient Mutant Mice

Received May 6, 1996; revised June 24, 1996; accepted June 25, 1996.
Michael S. Levine¹, Katharine L. Altemus¹, Carlos Cepeda¹, Howard C. Cromwell¹, Cynthia Crawford¹, Marjorie A. Ariano², John Drago³, David R. Sibley⁴, and Heiner Westphal⁵
¹ Mental Retardation Research Center, University of California, Los Angeles, Los Angeles, California 90024-1759, ² Department of Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064, ³ Anatomy Department, Monash University, Clayton, Victoria 3168, Australia, ⁴ Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, and ⁵ Laboratory of Mammalian Genes and Development, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892
The role of D₁ dopamine (DA) receptors in mediating the ability of DA to modulate responses attributable to activation of NMDA receptors was examined in mice lacking D_1A dopamine receptors. Specifically, experiments were designed to test the hypothesis that the ability of DA to potentiate responses mediated by activation of NMDA receptors was attributable to activation of D₁ receptors. Based on this hypothesis, we would predict that in the D_1A mutant mouse, either DA would not induce enhancement of NMDA-mediated responses, or the enhancement would be severely attenuated. The results provided evidence to support the hypothesis. In mutant mice, DA and D₁ receptor agonists did not potentiate responses mediated by activation of NMDA receptors. In contrast, in control mice, both DA and D₁ receptor agonists markedly potentiated responses mediated by activation of NMDA receptors. The effects of DA in attenuating responses mediated by activation of non-NMDA receptors also were altered in the mutant, suggesting that this action of DA may require coupling or interactions between D₁ and D₂ receptors. The present studies also provided an opportunity to assess some of the basic electrophysiological and morphological properties of neostriatal neurons in mice lacking D_1A DA receptors. Resting membrane potential, action potential parameters, input resistance, excitability, somatic size, dendritic extent, and estimates of spine density in mutants and controls were similar, suggesting that these basic neurophysiological and structural properties have not been changed by the loss of the D_1A DA receptor.

Key words: dopamine receptors; D₁; excitatory amino acid receptors; knock-out mice; mutant; neostriatal slices; NMDA

This article has been cited by other articles:

H. Tong and A. J. Gibb
Dopamine D1 receptor inhibition of NMDA receptor currents mediated by tyrosine kinase-dependent receptor trafficking in neonatal rat striatum
J. Physiol., October 1, 2008; 586(19): 4693 - 4707.
[Abstract] [Full Text] [PDF]

T.-S. Tang, X. Chen, J. Liu, and I. Bezprozvanny
Dopaminergic Signaling and Striatal Neurodegeneration in Huntington's Disease
J. Neurosci., July 25, 2007; 27(30): 7899 - 7910.
[Abstract] [Full Text] [PDF]

N. Wu, C. Cepeda, X. Zhuang, and M. S. Levine
Altered Corticostriatal Neurotransmission and Modulation in Dopamine Transporter Knock-Down Mice
J Neurophysiol, July 1, 2007; 98(1): 423 - 432.
[Abstract] [Full Text] [PDF]

P. J. Hallett, R. Spoelgen, B. T. Hyman, D. G. Standaert, and A. W. Dunah
Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking.
J. Neurosci., April 26, 2006; 26(17): 4690 - 4700.
[Abstract] [Full Text] [PDF]

C. R. Yang and L. Chen
Targeting Prefrontal Cortical Dopamine D1 and N-Methyl-D-Aspartate Receptor Interactions in Schizophrenia Treatment
Neuroscientist, October 1, 2005; 11(5): 452 - 470.
[Abstract] [PDF]

A. H. Tran, R. Tamura, T. Uwano, T. Kobayashi, M. Katsuki, and T. Ono
Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place
PNAS, February 8, 2005; 102(6): 2117 - 2122.
[Abstract] [Full Text] [PDF]

T.-S. Tang and I. Bezprozvanny
Dopamine Receptor-mediated Ca2+ Signaling in Striatal Medium Spiny Neurons
J. Biol. Chem., October 1, 2004; 279(40): 42082 - 42094.
[Abstract] [Full Text] [PDF]

K. Chergui, P. Svenningsson, and P. Greengard
Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
PNAS, February 17, 2004; 101(7): 2191 - 2196.
[Abstract] [Full Text] [PDF]

S.-P. Onn, A. A. Fienberg, and A. A. Grace
Dopamine Modulation of Membrane Excitability in Striatal Spiny Neurons is Altered in DARPP-32 Knockout Mice
J. Pharmacol. Exp. Ther., September 1, 2003; 306(3): 870 - 879.
[Abstract] [Full Text] [PDF]

C. Fiorentini, F. Gardoni, P. Spano, M. Di Luca, and C. Missale
Regulation of Dopamine D1 Receptor Trafficking and Desensitization by Oligomerization with Glutamate N-Methyl-D-aspartate Receptors
J. Biol. Chem., May 23, 2003; 278(22): 20196 - 20202.
[Abstract] [Full Text] [PDF]

C. Gonzalez-Islas and J. J. Hablitz
Dopamine Enhances EPSCs in Layer II-III Pyramidal Neurons in Rat Prefrontal Cortex
J. Neurosci., February 1, 2003; 23(3): 867 - 875.
[Abstract] [Full Text] [PDF]

J. Flores-Hernandez, C. Cepeda, E. Hernandez-Echeagaray, C. R. Calvert, E. S. Jokel, A. A. Fienberg, P. Greengard, and M. S. Levine
Dopamine Enhancement of NMDA Currents in Dissociated Medium-Sized Striatal Neurons: Role of D1 Receptors and DARPP-32
J Neurophysiol, December 1, 2002; 88(6): 3010 - 3020.
[Abstract] [Full Text] [PDF]

O.-J. Kim, M. A. Ariano, R. A. Lazzarini, M. S. Levine, and D. R. Sibley
Neurofilament-M Interacts with the D1 Dopamine Receptor to Regulate Cell Surface Expression and Desensitization
J. Neurosci., July 15, 2002; 22(14): 5920 - 5930.
[Abstract] [Full Text] [PDF]

S. Yasumoto, E. Tanaka, G. Hattori, H. Maeda, and H. Higashi
Direct and Indirect Actions of Dopamine on the Membrane Potential in Medium Spiny Neurons of the Mouse Neostriatum
J Neurophysiol, March 1, 2002; 87(3): 1234 - 1243.
[Abstract] [Full Text] [PDF]

J. Wang and P. O'Donnell
D1 Dopamine Receptors Potentiate NMDA-mediated Excitability Increase in Layer V Prefrontal Cortical Pyramidal Neurons
Cereb Cortex, May 1, 2001; 11(5): 452 - 462.
[Abstract] [Full Text] [PDF]

C. Cepeda, R. S. Hurst, K. L. Altemus, J. Flores-Hernandez, C. R. Calvert, E. S. Jokel, D. K. Grandy, M. J. Low, M. Rubinstein, M. A. Ariano, et al.
Facilitated Glutamatergic Transmission in the Striatum of D2 Dopamine Receptor-Deficient Mice
J Neurophysiol, February 1, 2001; 85(2): 659 - 670.
[Abstract] [Full Text] [PDF]

J. K. Seamans, D. Durstewitz, B. R. Christie, C. F. Stevens, and T. J. Sejnowski
Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons
PNAS, December 22, 2000; (2000) 11518798.
[Abstract] [Full Text]

B. L. Lewis and P. O'Donnell
Ventral Tegmental Area Afferents to the Prefrontal Cortex Maintain Membrane Potential 'Up' States in Pyramidal Neurons via D1 Dopamine Receptors
Cereb Cortex, December 1, 2000; 10(12): 1168 - 1175.
[Abstract] [Full Text] [PDF]

S. L. Smith-Roe and A. E. Kelley
Coincident Activation of NMDA and Dopamine D1 Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning
J. Neurosci., October 15, 2000; 20(20): 7737 - 7742.
[Abstract] [Full Text] [PDF]

A. A. Fienberg, N. Hiroi, P. G. Mermelstein, W. Song, G. L. Snyder, A. Nishi, A. Cheramy, J. P. O'Callaghan, D. B. Miller, D. G. Cole, et al.
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Science, August 7, 1998; 281(5378): 838 - 842.
[Abstract] [Full Text]

S. M. Nicola and R. C. Malenka
Modulation of Synaptic Transmission by Dopamine and Norepinephrine in Ventral but not Dorsal Striatum
J Neurophysiol, April 1, 1998; 79(4): 1768 - 1776.
[Abstract] [Full Text] [PDF]

C. Cepeda, C. S. Colwell, J. N. Itri, S. H. Chandler, and M. S. Levine
Dopaminergic Modulation of NMDA-Induced Whole Cell Currents in Neostriatal Neurons in Slices: Contribution of Calcium Conductances
J Neurophysiol, January 1, 1998; 79(1): 82 - 94.
[Abstract] [Full Text] [PDF]

F. Gonon
Prolonged and Extrasynaptic Excitatory Action of Dopamine Mediated by D1 Receptors in the Rat Striatum In Vivo
J. Neurosci., August 1, 1997; 17(15): 5972 - 5978.
[Abstract] [Full Text] [PDF]

J. Harvey and M. G. Lacey
A Postsynaptic Interaction between Dopamine D1 and NMDA Receptors Promotes Presynaptic Inhibition in the Rat Nucleus Accumbens via Adenosine Release
J. Neurosci., July 15, 1997; 17(14): 5271 - 5280.
[Abstract] [Full Text] [PDF]

N. A. Otmakhova and J. E. Lisman
D1/D5 Dopamine Receptor Activation Increases the Magnitude of Early Long-Term Potentiation at CA1 Hippocampal Synapses
J. Neurosci., December 1, 1996; 16(23): 7478 - 7486.
[Abstract] [Full Text] [PDF]

J. K. Seamans, D. Durstewitz, B. R. Christie, C. F. Stevens, and T. J. Sejnowski
Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons
PNAS, January 2, 2001; 98(1): 301 - 306.
[Abstract] [Full Text] [PDF]