 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 16, Number 19, Issue of October 1, 1996 pp. 6208-6218
Copyright ©1996 Society for NeuroscienceTrkA, But Not TrkC, Receptors Are Essential for Survival of Sympathetic Neurons In Vivo
Received April 22, 1996; revised July 16, 1996; accepted July 18, 1996.
Anne M. Fagan1, Hong Zhang2, Story Landis2, Richard J. Smeyne1, Inmaculada Silos-Santiago1, and Mariano Barbacid1 1 Department of Molecular Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, and 2 Department of Neuroscience, Case Western Reserve University, Cleveland, Ohio 44195
Neurotrophins and their signaling receptors, the Trk family of protein tyrosine kinases, play a major role in the development of the mammalian nervous system. To determine the precise stages that require Trk receptor signaling during development of the sympathetic system, we have analyzed the superior cervical ganglion (SCG) of embryonic and postnatal mice defective for each of the known Trk receptors. Transcripts encoding TrkC are detected in early sympathetic development, before the coalescence of the SCG. trkA expression appears at E13.5, becoming robust from E15.5 onward. In contrast, trkC expression decreases significantly after E15.5 and remains detectable only in a small subpopulation of cells. No significant trkB expression could be detected in the SCG at any developmental stage. Ablation of TrkA receptors does not affect neurogenesis, expression of neuronal markers, or initial axonal growth. However, these receptors are absolutely necessary for the survival of sympathetic neurons after E15.5 and for proper innervation of their distal targets. In contrast, mice defective for either TrkC or TrkB tyrosine kinase receptors do not display detectable defects in their SCGs. These results illustrate the differential roles of the Trk family of receptors during SCG development and define a critical role for TrkA signaling in the survival, but not differentiation, of SCG neurons. Moreover, these observations raise the possibility that at least some SCG neurons become neurotrophin-dependent before complete target innervation.
Key words: Trk receptors; neurotrophins; superior cervical ganglion; sympathetic neurons; neuronal survival; knockout mice
This article has been cited by other articles:
D. Bodmer, S. Levine-Wilkinson, A. Richmond, S. Hirsh, and R. Kuruvilla
Wnt5a Mediates Nerve Growth Factor-Dependent Axonal Branching and Growth in Developing Sympathetic Neurons
J. Neurosci., June 10, 2009; 29(23): 7569 - 7581.
[Abstract] [Full Text] [PDF]
G. M. Brodeur, J. E. Minturn, R. Ho, A. M. Simpson, R. Iyer, C. R. Varela, J. E. Light, V. Kolla, and A. E. Evans
Trk Receptor Expression and Inhibition in Neuroblastomas
Clin. Cancer Res., May 15, 2009; 15(10): 3244 - 3250.
[Abstract] [Full Text] [PDF]
L. C. Eldredge, X. M. Gao, D. H. Quach, L. Li, X. Han, J. Lomasney, and W. G. Tourtellotte
Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice
Development, September 1, 2008; 135(17): 2949 - 2957.
[Abstract] [Full Text] [PDF]
K. M. Albers and B. M. Davis
The Skin as a Neurotrophic Organ
Neuroscientist, August 1, 2007; 13(4): 371 - 382.
[Abstract] [PDF]
S. Rassadi, A. Krishnaswamy, B. Pie, R. McConnell, M. H. Jacob, and E. Cooper
A Null Mutation for the {alpha}3 Nicotinic Acetylcholine (ACh) Receptor Gene Abolishes Fast Synaptic Activity in Sympathetic Ganglia and Reveals That ACh Output from Developing Preganglionic Terminals Is Regulated in an Activity-Dependent Retrograde Manner
J. Neurosci., September 14, 2005; 25(37): 8555 - 8566.
[Abstract] [Full Text] [PDF]
N. O. Glebova and D. D. Ginty
Heterogeneous Requirement of NGF for Sympathetic Target Innervation In Vivo
J. Neurosci., January 21, 2004; 24(3): 743 - 751.
[Abstract] [Full Text] [PDF]
D. W Munno and N. I Syed
Synaptogenesis in the CNS: An Odyssey from Wiring Together to Firing Together
J. Physiol., October 1, 2003; 552(1): 1 - 11.
[Abstract] [Full Text] [PDF]
G. Pelicci, F. Troglio, A. Bodini, R. M. Melillo, V. Pettirossi, L. Coda, A. De Giuseppe, M. Santoro, and P. G. Pelicci
The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway
Mol. Cell. Biol., October 15, 2002; 22(20): 7351 - 7363.
[Abstract] [Full Text] [PDF]
G. Middleton and A. M. Davies
Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo
Development, December 1, 2001; 128(23): 4715 - 4728.
[Abstract] [Full Text] [PDF]
H. Enomoto, P. A. Crawford, A. Gorodinsky, R. O. Heuckeroth, E. M. Johnson Jr., and J. Milbrandt
RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons
Development, October 15, 2001; 128(20): 3963 - 3974.
[Abstract] [Full Text] [PDF]
L. A. Plum, L. F. Parada, P. Tsoulfas, and M. Clagett-Dame
Retinoic Acid Combined with Neurotrophin-3 Enhances the Survival and Neurite Outgrowth of Embryonic Sympathetic Neurons
Experimental Biology and Medicine, September 1, 2001; 226(8): 766 - 775.
[Abstract] [Full Text] [PDF]
A. Edsjö, B. Hallberg, S. Fagerström, C. Larsson, H. Axelson, and S. Påhlman
Differences in Early and Late Responses between Neurotrophin-stimulated trkA- and trkC-transfected SH-SY5Y Neuroblastoma Cells
Cell Growth Differ., January 1, 2001; 12(1): 39 - 50.
[Abstract] [Full Text]
M. Bibel and Y.-A. Barde
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system
Genes & Dev., December 1, 2000; 14(23): 2919 - 2937.
[Full Text]
C. D. Pozniak, S. Radinovic, A. Yang, F. McKeon, D. R. Kaplan, and F. D. Miller
An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death
Science, July 14, 2000; 289(5477): 304 - 306.
[Abstract] [Full Text]
C. J. Kim, T. Matsuo, K.-H. Lee, and C. J. Thiele
Up-Regulation of Insulin-Like Growth Factor-II Expression Is a Feature of TrkA but Not TrkB Activation in SH-SY5Y Neuroblastoma Cells
Am. J. Pathol., November 1, 1999; 155(5): 1661 - 1670.
[Abstract] [Full Text] [PDF]
S. Wyatt, G. Middleton, E. Doxakis, and A. M. Davies
Selective Regulation of trkC Expression by NT3 in the Developing Peripheral Nervous System
J. Neurosci., August 1, 1999; 19(15): 6559 - 6570.
[Abstract] [Full Text] [PDF]
M. Sondell, G. Lundborg, and M. Kanje
Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System
J. Neurosci., July 15, 1999; 19(14): 5731 - 5740.
[Abstract] [Full Text] [PDF]
T. Debeir, H. U. Saragovi, and A. C. Cuello
A nerve growth factor mimetic TrkA antagonist causes withdrawal of cortical cholinergic boutons in the adult rat
PNAS, March 30, 1999; 96(7): 4067 - 4072.
[Abstract] [Full Text] [PDF]
S. I. Lentz, C. M. Knudson, S. J. Korsmeyer, and W. D. Snider
Neurotrophins Support the Development of Diverse Sensory Axon Morphologies
J. Neurosci., February 1, 1999; 19(3): 1038 - 1048.
[Abstract] [Full Text] [PDF]
X.-M. Yang, J. G. Toma, S. X. Bamji, D. J. Belliveau, J. Kohn, M. Park, and F. D. Miller
Autocrine Hepatocyte Growth Factor Provides a Local Mechanism for Promoting Axonal Growth
J. Neurosci., October 15, 1998; 18(20): 8369 - 8381.
[Abstract] [Full Text] [PDF]
J. Oberdoerster, A. R. Kamer, and R. A. Rabin
Differential Effect of Ethanol on PC12 Cell Death
J. Pharmacol. Exp. Ther., October 1, 1998; 287(1): 359 - 365.
[Abstract] [Full Text]
D. Zhang, M. F. Mehler, Q. Song, and J. A. Kessler
Development of Bone Morphogenetic Protein Receptors in the Nervous System and Possible Roles in Regulating trkC Expression
J. Neurosci., May 1, 1998; 18(9): 3314 - 3326.
[Abstract] [Full Text] [PDF]
L. Tessarollo, P. Tsoulfas, M. J. Donovan, M. E. Palko, J. Blair-Flynn, B. L. Hempstead, and L. F. Parada
Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis
PNAS, December 23, 1997; 94(26): 14776 - 14781.
[Abstract] [Full Text] [PDF]
A. M. Fagan, M. Garber, M. Barbacid, I. Silos-Santiago, and D. M. Holtzman
A Role for TrkA during Maturation of Striatal and Basal Forebrain Cholinergic Neurons In Vivo
J. Neurosci., October 15, 1997; 17(20): 7644 - 7654.
[Abstract] [Full Text] [PDF]
J. J. Toledo-Aral, B. L. Moss, Z.-J. He, A. G. Koszowski, T. Whisenand, S. R. Levinson, J. J. Wolf, I. Silos-Santiago, S. Halegoua, and G. Mandel
Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons
PNAS, February 18, 1997; 94(4): 1527 - 1532.
[Abstract] [Full Text] [PDF]
C. Brodski, H. Schnurch, and G. Dechant
Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons
PNAS, August 15, 2000; 97(17): 9683 - 9688.
[Abstract] [Full Text] [PDF]
M. Majdan, G. S. Walsh, R. Aloyz, and F. D. Miller
TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal
J. Cell Biol., December 24, 2001; 155(7): 1275 - 1286.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|