 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 16, 467-477, Copyright © 1996 by Society for Neuroscience
Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein
A Holz, N Schaeren-Wiemers, C Schaefer, U Pott, RJ Colello and ME Schwab
Brain Research Institute, University of Zurich, Switzerland.
Several novel myelin-associated/oligodendrocytic basic protein (MOBP)
isoforms were identified in this study by cDNA cloning. They are small,
highly basic polypeptides comprising 69, 81, and 99 amino acids (8.2, 9.7,
and 11.7 kDa, respectively) and show no significant homology with described
proteins or domain structures. All (as yet) identified MOBP isoforms are
identical in amino acids 1-68 but differ in the length and polarity of the
C-terminal region. One isoform, designated MOBP81, was shown to be
expressed abundantly during development. Interestingly, MOBP81 has a
significant clustering of positively charged residues at positions 69-81, a
feature that also has been observed for myelin basic protein (MBP) and Po.
As demonstrated by in situ hybridization, MOBP gene expression occurs
during development of the rat optic nerve later than that of MBP and
proteolipid protein and coincides exactly with the beginning of myelin
compaction. The 2.6 kb MOBP81-A transcript is localized in the processes of
oligodendrocytes, whereas the 3.8 kb MOBP81-B transcript is restricted to
the perinuclear region. Therefore, MOBP81-A and related mRNAs seem to be
transported to the periphery of the oligodendrocytes, as is known for the
transcripts of the MBP gene. The late developmental expression of the MOBP
gene suggests that the MOBP proteins act at the late steps of myelin
formation, possibly in myelin compaction and in the maintenance of the
myelin sheath.
This article has been cited by other articles:
|
|
|
|
 
V. P. Francone, M. J. Maggipinto, L. D. Kosturko, and E. Barbarese
The Microtubule-Associated Protein Tumor Overexpressed Gene/Cytoskeleton-Associated Protein 5 Is Necessary for Myelin Basic Protein Expression in Oligodendrocytes
J. Neurosci.,
July 18, 2007;
27(29):
7654 - 7662.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Zagrebelsky, A. Holz, G. Dechant, Y.-A. Barde, T. Bonhoeffer, and M. Korte
The p75 Neurotrophin Receptor Negatively Modulates Dendrite Complexity and Spine Density in Hippocampal Neurons
J. Neurosci.,
October 26, 2005;
25(43):
9989 - 9999.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sun, Y. Zhang, B. Wei, S. C. Peiper, H. Shao, and H. J. Kaplan
Encephalitogenic activity of truncated myelin oligodendrocyte glycoprotein (MOG) peptides and their recognition by CD8+ MOG-specific T cells on oligomeric MHC class I molecules
Int. Immunol.,
February 1, 2003;
15(2):
261 - 268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ishibashi, J. L. Dupree, K. Ikenaka, Y. Hirahara, K. Honke, E. Peles, B. Popko, K. Suzuki, H. Nishino, and H. Baba
A Myelin Galactolipid, Sulfatide, Is Essential for Maintenance of Ion Channels on Myelinated Axon But Not Essential for Initial Cluster Formation
J. Neurosci.,
August 1, 2002;
22(15):
6507 - 6514.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sun, J. N. Whitaker, Z. Huang, D. Liu, C. Coleclough, H. Wekerle, and C. S. Raine
Myelin Antigen-Specific CD8+ T Cells Are Encephalitogenic and Produce Severe Disease in C57BL/6 Mice
J. Immunol.,
June 15, 2001;
166(12):
7579 - 7587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. Tiwari-Woodruff, A. G. Buznikov, T. Q. Vu, P. E. Micevych, K. Chen, H. I. Kornblum, and J. M. Bronstein
OSP/Claudin-11 Forms a Complex with a Novel Member of the Tetraspanin Super Family and {beta}1 Integrin and Regulates Proliferation and Migration of Oligodendrocytes
J. Cell Biol.,
April 16, 2001;
153(2):
295 - 306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sevilla, S. Kunz, A. Holz, H. Lewicki, D. Homann, H. Yamada, K. P. Campbell, J. C. de la Torre, and M. B.A. Oldstone
Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells
J. Exp. Med.,
October 30, 2000;
192(9):
1249 - 1260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Holz, B. Bielekova, R. Martin, and M. B. A. Oldstone
Myelin-Associated Oligodendrocytic Basic Protein: Identification of an Encephalitogenic Epitope and Association with Multiple Sclerosis
J. Immunol.,
January 15, 2000;
164(2):
1103 - 1109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ainger, D. Avossa, A. S. Diana, C. Barry, E. Barbarese, and J. H. Carson
Transport and Localization Elements in Myelin Basic Protein mRNA
J. Cell Biol.,
September 8, 1997;
138(5):
1077 - 1087.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
