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Journal of Neuroscience, Vol 16, 506-518, Copyright © 1996 by Society for Neuroscience
Developmental expression and functional characterization of the potassium-channel subunit Kv3.1b in parvalbumin-containing interneurons of the rat hippocampus
J Du, L Zhang, M Weiser, B Rudy and CJ McBain
Unit on Cellular and Synaptic Physiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-4495, USA.
The expression of the voltage-gated K(+)-channel subunit Kv3.1b in the
developing hippocampus was determined by immunoblot and immunohistochemical
techniques. Kv3.1b protein was detected first at postnatal day (P) 8. The
Kv3.1b-immunopositive cell number per tissue section reached a maximum at
P14 and was maintained through P40. In contrast, the Kv3.1b protein content
of isolated membrane vesicles in immunoblots progressively increased
through P40, suggesting an increase in Kv3.1b content per cell throughout
this time period. Kv3.1b protein was expressed selectively in the somata,
proximal dendrites, and axons of cells lying within or near the pyramidal
cell layer, consistent with their being GABAergic inhibitory interneurons.
Kv3.1b was present in approximately 80% of parvalbumin-positive
interneurons. The developmental onset of Kv3.1b and parvalbumin
immunoreactivity was identical. In contrast, Kv3.1b was mostly absent from
the subset of somatostatin-positive inhibitory interneurons.
Electrophysiological recordings were made from stratum pyramidale
interneurons in which morphology and Kv3.1b-positive immunoreactivity were
confirmed post hoc. Outward currents had voltage-dependent and biophysical
properties resembling those of channels formed by Kv3.1b. The current
blocked by low concentrations of 4-aminopyridine (4-AP) showed marked
inactivation, suggesting that Kv3.1b may coassemble with other members of
the Kv3 subfamily. In current-clamp recordings, concentrations of 4- AP
that blocked the current through Kv3.1b channels allowed us tentatively to
assign a role to Kv3.1b-containing channels in action- potential
repolarization. These data demonstrate that Kv3.1b is regulated
developmentally in a specific subpopulation of hippocampal interneurons and
that channels containing this subunit may be a major determinant in
imparting "fast-spiking" characteristics to these and other cells
throughout the central nervous system containing the Kv3.1b subunit.
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