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Journal of Neuroscience, Vol 16, 605-611, Copyright © 1996 by Society for Neuroscience
The role of adenosine A2a receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons
A Mori, T Shindou, M Ichimura, H Nonaka and H Kase
Pharmaceutical Research Laboratory Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
We demonstrated an adenosine A2a receptor-mediated disinhibition of medium
spiny projection neurons using intracellular recording and the whole-cell
patch-clamp recording applied to these cells, visually identified in thin
rat striatal slices. The A2a receptor agonist 2-[p- (2-carboxyethyl)
phenylethylamino]-5'-N- ethylcarboxamido adenosine (CGS-21680; 0.3-10
microM) suppressed GABAergic synaptic transmission onto these cells in a
manner inhibited by the A2a receptor-selective antagonist
(E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine (0.1-1.0 microM).
The A1 receptor antagonists had no effect on the CGS- 21680-induced
suppression. Analysis of spontaneous miniature inhibitory synaptic currents
indicated that suppression of intrastriatal GABAergic synaptic transmission
was attributable to presynaptic, but not postsynaptic, A2a receptors.
Therefore, the A2a receptor may regulate striatal output activity by
relieving GABA-mediated inhibition of the medium spiny projection neurons,
which explains the ability of purinergic agents to affect motor control.
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